- •Mildly elevated unconjugated bilirubin (UCB) might mitigate cardiovascular disease risk factors including overweight/obesity.
- •Gilbert's syndrome(GS) subjects with mildly elevated UCB were metabolically healthier than age- and gender matched controls.
- •The condition of mild hyperbilirubinaemia (GS) seems to protect from age-related weight gain and dyslipidaemia.
Background and aims
Mild endogenous elevation of unconjugated bilirubin (UCB) as seen in Gilbert's syndrome (GS), might mitigate cardiovascular disease (CVD) risk factors including overweight/obesity. This study aimed to determine whether hyperbilirubinaemia is linked to improved anthropometric data and lipid profile.
Our study considered GS and age-/gender-matched healthy controls (n = 248). Additionally, obese female type 2 diabetic patients (DM2) (n = 26) were included as a “disease control group”.
BMI, hip circumference (HC), and lipid profile were significantly lower in GS. UCB was inversely correlated with BMI (p <0 .001), HC as well as with fat mass (FM) and lipid variables (p < 0.05). Moreover, DM2 patients had significantly lower UCB compared to GS and healthy controls. Older GS subjects (≥35 years) had significantly reduced anthropometric data and improved lipid profile.
Our results propose that the health promoting potential of mild hyperbilirubinaemia may extend to protection from age-related weight gain and dyslipidaemia.
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Published online: December 14, 2017
Accepted: December 12, 2017
Received in revised form: December 12, 2017
Received: June 8, 2017
© 2017 Elsevier B.V. All rights reserved.