- •Viral infections have been linked to atherosclerosis and cardiovascular events.
- •Inconsistent study results reported regarding the atherosclerotic potential by viral hepatitis B and C.
- •There exist no direct comparison for the effect of viral hepatitis B and C on atherosclerosis.
- •Patients with HCV had significantly increased risks in cardiovascular events compared to patients with HBV.
Background and aims
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- Infection and atherosclerosis: emerging mechanistic paradigms.Circulation. 1999; 100: e20-e28
- Pathogens and atherosclerosis - update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis.Thromb. Haemostasis. 2011; 106: 858-867
- Chlamydia pneumoniae is likely a risk factor for ischemic stroke in young patients.J. Stroke Cerebrovasc. Dis. 2004; 13: 85-91
- Accelerated coronary atherosclerosis and arteriosclerosis in young human-immunodeficiency-virus-positive patients.Coron. Artery Dis. 2000; 11: 41-46
- Risk of acute stroke after hospitalization for sepsis: a case-crossover study.Stroke. 2017; 48: 574-580
- Risk of acute coronary heart disease after sepsis hospitalization in the reasons for geographic and racial differences in stroke cohort.Clin. Infect. Dis. 2017 Mar 23; ([Epub ahead of print])https://doi.org/10.1093/cid/cix248
- Cytomegalovirus infection of rats increases the neointimal response to vascular injury without consistent evidence of direct infection of the vascular wall.Circulation. 1999; 100: 1569-1575
- Effects of human cytomegalovirus immediate-early proteins on p53-mediated apoptosis in coronary artery smooth muscle cells.Circulation. 1999; 99: 1656-1659
- Chlamydia pneumoniae, cytomegalovirus, and herpes simplex virus in atherosclerosis of the carotid artery.Circulation. 1997; 96: 2144-2148
- Herpesvirus in atherosclerosis and thrombosis: etiologic agents or ubiquitous bystanders?.Arterioscler. Thromb. Vasc. Biol. 1998; 18: 339-348
- The possible role of hepatitis A virus in the pathogenesis of atherosclerosis.J. Infect. Dis. 2000; 182: 1583-1587
- Increased prevalence of carotid atherosclerosis in hepatitis B virus carriers.Circulation. 2002; 105: 1028-1030
- Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening.Lancet. 2002; 359: 133-135
- Hepatitis B virus seropositivity and the risk of stroke and myocardial infarction.Stroke. 2007; 38: 1436-1441
- Hepatitis C virus infection and the risk of coronary disease.Clin. Infect. Dis. 2009; 49: 225-232
- Hepatitis B and C virus infection and the risk of atherosclerosis in a general population.Atherosclerosis. 2014; 174: 99-103
National Health Insurance Research Database, Taiwan. https://nhird.nhri.org.tw/en/Data_Subsets.html.
- Association between nucleoside analogues and risk of hepatitis B virus-related hepatocellular carcinoma recurrence following liver resection.JAMA. 2012; 308: 1906-1914
- A proportional hazards model for the subdistribution of a competing risk.J. Am. Stat. Assoc. 1999; 94: 496-509
- The relationship between acute infectious diseases and arterial lesions.Arch. Intern. Med. 1911; 8: 153-162
- Arteriosclerosis and cardiovascular disease: their relation to infectious diseases.JAMA. 1921; 76: 700-701
- Atheroarteriosclerosis induced by infection with a herpesvirus.Am. J. Pathol. 1979; 96: 673-706
- Herpesvirus infection enhances cholesterol and cholesteryl ester accumulation in cultured arterial smooth muscle cells.Am. J. Pathol. 1981; 105: 176-184
- Immunology of atherosclerosis demonstration of heat shock protein and T-lymphocytes bearing α/β or γ/δ receptor in human atherosclerotic lesions.Am. J. Pathol. 1993; 142: 1927-1937
- Staining of endothelial cells and macrophages in atherosclerotic lesions with human heat-shock protein-reactive antisera.Arterioscler. Thromb. 1993; 13: 1763-1769
- T lymphocytes from human atherosclerotic plaques recognize oxidized LDL.Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 3892-3897
- Induction of endogenous cytomegalovirus gene expression after differentiation of monocytes from healthy carriers.J. Virol. 1994; 68: 1597-1604
- Monocytes harboring cytomegalovirus: interactions with endothelial cells, smooth muscle cells and oxidized low density lipoprotein: possible mechanisms for activating virus delivered by monocytes to sites of vascular injury.Circ. Res. 1997; 81: 8-16
- Insights into the role of infection in plaque rupture.Circulation. 2009; 119: 3133-3141
- Chronic hepatitis B infection and risk of atherosclerosis-related mortality: a 17-year follow-up study based on 22,472 residents in Taiwan.Atherosclerosis. 2010; 211: 624-629
- Hepatitis virus infection and decreased risk of stroke: a meta-analysis.Oncotarget. 2017; 8: 59658-59665
- Hepatitis C virus infection is associated with increased cardiovascular mortality: a meta-analysis of observational studies.Gastroeneterology. 2016; 150: 145-155