Highlights
- •This study investigates the effect of brachial and central BP on serum concentrations of hs-cTnI.
- •Serum concentrations of hs-cTnI increase with increasing brachial and central BP.
- •In subjects with increased arterial stiffness, the effect of central BP on serum concentrations of hs-cTnI was greater.
- •These associations remained significant after further adjustment for BNP and/or oxidative marker.
- •Central BP may have a strong effect on silent myocardial damage.
Abstract
Background and aims
Severe cardiac load increases circulating concentrations of high-sensitivity cardiac
troponin I (hs-cTnI) through non-ischemic mechanisms. The present study was designed
to investigate the effect of central blood pressure (BP), which reflects cardiac load
rather than peripheral BP, on serum concentrations of hs-cTnI in subjects with or
without increased arterial stiffness.
Methods
We enrolled 1210 participants taking part in a yearly health checkup program. Laboratory
measurements included serum concentrations of hs-cTnI and derivative reactive oxygen
metabolites (d-ROM), as well as plasma concentrations of B-type natriuretic peptide
(BNP). Central BP and the radial augmentation index (rAI) were evaluated non-invasively
using an automated device.
Results
Univariate and multivariable regression analysis showed that both brachial and central
BP were significantly associated with hs-cTnI. When subjects were divided into two
groups according to the mean rAI value, those with higher rAI had higher hs-cTnI concentrations
than those with lower rAI. In subgroup analyses, in those with lower rAI, brachial
but not central systolic BP was independently associated with hs-cTnI, whereas in
those with higher rAI, central but not brachial systolic BP was independently associated
with hs-cTnI. These associations remained significant after further adjustment for
BNP and/or d-ROM concentrations.
Conclusions
Circulating levels of hs-cTnI increase with increasing brachial and central BP, but
the effect of central BP was greater in subjects with higher rAI. This indicates that
central BP may have a strong effect on silent myocardial damage, assessed as increased
circulating hs-cTnI, particularly in subjects with increased arterial stiffness.
Keywords
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Article Info
Publication History
Published online: January 15, 2018
Accepted:
January 12,
2018
Received in revised form:
November 21,
2017
Received:
July 20,
2017
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
