Highlights
- •The overall incidence rates of acute coronary syndrome (ACS) and peripheral arterial disease (PAD) were 2.81 and 2.97 per 1000 person-years, respectively, in the cirrhosis cohort.
- •The cirrhosis cohort had a significantly higher risks of ACS (adjusted subhazard ratio (aSHR) = 1.12) and PAD (aSHR = 1.11).
Abstract
Background & aims
Until now, no study has investigated the risks of acute coronary syndrome (ACS) and
peripheral arterial disease (PAD) in cirrhosis.
Methods
In this study, 57,214 patients diagnosed with cirrhosis between 2000 and 2010 were
identified from the Taiwan National Health Insurance claims data. Each patient was
randomly selected and frequency-matched with an individual without cirrhosis by age,
sex, and index year.
Results
The overall incidence rates of ACS and PAD were 2.81 and 2.97 per 1000 person-years,
respectively, in the cirrhosis cohort. The cirrhosis cohort had a higher risk of ACS
[adjusted subhazard ratio (aSHR) = 1.12, 95% confidence interval (CI) = 1.03–1.22]
and PAD (aSHR = 1.11, 95% CI = 1.02–1.21). The risk of ACS was highest among members
of the cirrhosis cohort with ascites (aSHR = 1.09, 95% CI = 1.11–1.19).
Conclusions
Patients with chronic liver disease and cirrhosis have higher risks of ACS and PAD
than those without chronic liver disease and cirrhosis.
Keywords
Abbreviations:
ACS (acute coronary syndrome), PAD (peripheral arterial disease), aSHR (adjusted subhazard ratio), HBV (hepatitis B virus), HCV (hepatitis C virus (HCV)), NHIRD (National Health Insurance Research Database), ICD-9-CM (International Classification of Diseases), Ninth Revision (Clinical Modification), CLDC (chronic liver disease and cirrhosis)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: February 04, 2018
Accepted:
January 31,
2018
Received in revised form:
January 29,
2018
Received:
November 11,
2017
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
