- •We identified patients at the 5% extremes of atherosclerosis, and measured metabolic products of the intestinal microbiome.
- •Patients with excess plaque (Unexplained) had higher levels of the metabolites, whereas patients with unexpectedly less plaque (Protected) had lower levels.
- •The differences were not explained by renal function or dietary intake of precursors.
- •TMAO and p-cresyl sulfate were independent predictors of carotid plaque burden.
- •New approaches to treating atherosclerosis, such as fecal repopulation or probiotics are suggested by these findings.
Background and aims
Abbreviations:ADMA (asymmetric dimethylarginine), CKD (chronic kidney disease), DNA (deoxyribonucleic acid), FFQ (food frequency questionnaire), GDUT (gut-derived uremic toxins), RES (residual score in linear regression), RNA (ribonucleic acid), TMAO (trimethylamine N-oxide), TPA (total plaque area)
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