Abstract| Volume 275, e32, August 2018

The lipid-droplet associated protein perilipin 2 (PLIN2) plays a central role in lipid accumulation and cholesterol efflux via effects on LXR signaling in human macrophages

      Aim: Cholesterol efflux is crucial in removing excess cholesterol from macrophage foam cells and is of importance in reducing atherosclerosis. Macrophages store lipids in lipid droplets (LDs) and perilipin 2 (PLIN2) is the major LD-associated protein. Thus we hypothesized that alterations of PLIN2 function affect macrophage lipid storage and can redirect intracellular cholesterol towards efflux pathways.
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