Aim: Cholesterol efflux is crucial in removing excess cholesterol from macrophage foam
cells and is of importance in reducing atherosclerosis. Macrophages store lipids in
lipid droplets (LDs) and perilipin 2 (PLIN2) is the major LD-associated protein. Thus
we hypothesized that alterations of PLIN2 function affect macrophage lipid storage
and can redirect intracellular cholesterol towards efflux pathways.
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© 2018 Published by Elsevier Inc.
