Abstract| Volume 275, e167-e168, August 2018

Defective HDL remodeling and macrophage cholesterol efflux in adult and adolescent familial hypercholesterolemic patients

      Aim: Familial hypercholesterolemic (FH) patients show qualitative abnormalities in the HDL particles that may be critical for HDL remodeling and macrophage cholesterol efflux. In the present study, we evaluated the HDL-associated master remodeling lipid transfer proteins and enzymes and their potential to alter HDL composition and macrophage cholesterol efflux in non-treated FH subjects with an identified LDLR mutation and in normolipidemic subjects matched for age and sex.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect