Aim: Familial hypercholesterolemic (FH) patients show qualitative abnormalities in the HDL particles that may be critical for HDL remodeling and macrophage cholesterol efflux. In the present study, we evaluated the HDL-associated master remodeling lipid transfer proteins and enzymes and their potential to alter HDL composition and macrophage cholesterol efflux in non-treated FH subjects with an identified LDLR mutation and in normolipidemic subjects matched for age and sex.
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