Aim: We previously demonstrated that both antioxidant property of HDL measured by Oxygen
Radical Absorbance Capacity (ORAC) assay and cholesterol efflux capacity (CEC) were
independently and inversely associated with the presence of atherosclerotic cardiovascular
disease (ASCVD) in familial hypercholesterolemia (FH) patients. Although these values
are better surrogate risk markers rather than plasma HDL-C level, it is impossible
to standardize them because of using cultured cells and pooled plasma. Accordingly,
we are trying to explore specific lipids in HDL fraction involving in HDL functionalities
as well as ASCVD risk. In this study, we aimed to investigate the effect of alpha-tocopherol
concentration in HDL fraction (AT-HDL) on HDL functionalities and the presence of
ASCVD in 264 statin-treated FH patients.
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© 2018 Published by Elsevier Inc.
