Aim: We previously demonstrated that both antioxidant property of HDL measured by Oxygen Radical Absorbance Capacity (ORAC) assay and cholesterol efflux capacity (CEC) were independently and inversely associated with the presence of atherosclerotic cardiovascular disease (ASCVD) in familial hypercholesterolemia (FH) patients. Although these values are better surrogate risk markers rather than plasma HDL-C level, it is impossible to standardize them because of using cultured cells and pooled plasma. Accordingly, we are trying to explore specific lipids in HDL fraction involving in HDL functionalities as well as ASCVD risk. In this study, we aimed to investigate the effect of alpha-tocopherol concentration in HDL fraction (AT-HDL) on HDL functionalities and the presence of ASCVD in 264 statin-treated FH patients.
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