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Real-life LDL-C treatment goals achievement in patients with heterozygous familial hypercholesterolemia in the Czech Republic and Slovakia: Results of the PLANET registry

  • Michal Vrablik
    Affiliations
    Third Department of Internal Medicine, General University Hospital and First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
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  • Katarina Raslová
    Affiliations
    Coordination Centre for Familial Hypercholesterolemia and Institute of Nutrition, Slovak Medical University, Limbova 14, 833 03 Bratislava, Slovak Republic
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  • Branislav Vohnout
    Affiliations
    Coordination Centre for Familial Hypercholesterolemia and Institute of Nutrition, Slovak Medical University, Limbova 14, 833 03 Bratislava, Slovak Republic
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  • Vladimir Blaha
    Affiliations
    Internal Gerontometabolic Department, University Hospital Hradec Kralove, Sokolska 408, 500 05 Hradec Kralove, Czech Republic
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  • Martin Satny
    Affiliations
    Third Department of Internal Medicine, General University Hospital and First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
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  • Ondrej Kyselak
    Affiliations
    Department of Clinical Biochemistry and the International Clinical Research Center – Department of Cardiovascular Diseases, St. Anne's University Hospital Brno, Pekarska 53, 656 91 Brno, Czech Republic
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  • Martina Vaclova
    Affiliations
    Third Department of Internal Medicine, General University Hospital and First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
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  • Robin Urbanek
    Affiliations
    Obezita-Ormiga, Koterova 5546, 760 01 Zlin, Czech Republic
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  • Jana Maskova
    Affiliations
    NEOX Clinical Research, V Jame 1, 110 00 Prague 1, Czech Republic
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  • Vladimir Soska
    Affiliations
    Department of Clinical Biochemistry and the International Clinical Research Center – Department of Cardiovascular Diseases, St. Anne's University Hospital Brno, Pekarska 53, 656 91 Brno, Czech Republic

    Second Department of Internal Medicine, Faculty of Medicine Masaryk University and St. Anne's University Hospital Brno, Pekarska 53, 656 91 Brno, Czech Republic
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  • Tomas Freiberger
    Correspondence
    Corresponding author. Centre for Cardiovascular Surgery and Transplantation, Pekarska 53, 656 91 Brno, Czech Republic.
    Affiliations
    Centre for Cardiovascular Surgery and Transplantation, Pekarska 53, 656 91 Brno, Czech Republic

    Ceitec and Medical Faculty of Masaryk University, Zerotinovo nam. 617/9, 601 77 Brno, Czech Republic
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      Highlights

      • 15.4% of patients with heterozygous FH achieved LDL-C goal attainment
      • High intensity lipid-lowering therapy was used by 54.6% patients
      • The longer the care by a specialist, the higher the probability of LDL-C goal attainment

      Abstract

      Background and aims

      Despite the high prevalence of familial hypercholesterolemia (FH) and available effective lipid-lowering therapy, most of the individuals with this disorder remain undiagnosed and undertreated. The aim of the PLANET registry was to assess the real-life attainment of low-density lipoprotein cholesterol (LDL-C) therapeutic target level in patients with heterozygous FH, to characterize prescribed lipid-lowering therapy with assessment of its efficiency according to the attainment of the target LDL-C level, and to characterize cardiovascular events observed in this patient population again in relation to LDL-C target level attainment.

      Methods

      PLANET registry was designed as a non-interventional, retrospective, cross-sectional, multicentre disease registry for adult patients with heterozygous FH in the Czech Republic and Slovakia.

      Results

      Overall, 1755 patients were enrolled at 32 sites specialized in FH treatment. 15.4% of patients attained the target LDL-C value. The proportion of patients with LDL-C goal achievement increased to 17.3% in the subgroup of patients receiving high-intensity statin therapy (54.6% of study population). Out of 55 patients receiving inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9), 61.8% reached the LDL-C treatment goal. Of all cardiovascular events reported, 14.0% occurred in patients attaining the LDL-C goal, while it was 86.0% in the not-at-target group. It was documented (p=0.004) that the longer is the patient in care at the specialized FH centre, the higher is the probability that he/she will attain the target LDL-C level.

      Conclusions

      Although target LDL-C level attainment remains relatively low, the likelihood of LDL-C goal attainment increases with duration of specialized care.

      Keywords

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