Aim: We recently showed that activation of brown adipose tissue (BAT) protects from atherosclerosis
development by reducing hypercholesterolemia (Nat Commun 2015) and enhancing reverse
cholesterol transport (Nat Commun 2017). A potential novel target to activate BAT
is the G protein-coupled receptor 120 (GPR120), which expression is strongly increased
by cold exposure in both white and brown fat, suggesting a role for GPR120 in thermogenesis.
Therefore, we aimed to elucidate the importance of GPR120 for BAT activity.
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© 2018 Published by Elsevier Inc.
