Aim: We recently showed that activation of brown adipose tissue (BAT) protects from atherosclerosis development by reducing hypercholesterolemia (Nat Commun 2015) and enhancing reverse cholesterol transport (Nat Commun 2017). A potential novel target to activate BAT is the G protein-coupled receptor 120 (GPR120), which expression is strongly increased by cold exposure in both white and brown fat, suggesting a role for GPR120 in thermogenesis. Therefore, we aimed to elucidate the importance of GPR120 for BAT activity.
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