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An update on statins: Pleiotropic effect performed in intracerebral hemorrhage

  • Qianwei Chen
    Affiliations
    Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China
    Department of Neurosurgery, Air Force Hospital of Western Theater, Chengdu, Sichuan, 610021, China
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  • Jianbo Zhang
    Affiliations
    Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China
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  • Hua Feng
    Affiliations
    Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China
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  • Zhi Chen
    Correspondence
    Corresponding author. Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), No. 30, Gaotanyan Street, Chongqing, 400038, China.
    Affiliations
    Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China
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      We read with interest the recent article by Chung et al. [
      • Chung C.M.
      • Lin M.S.
      • Liu C.H.
      • et al.
      Discontinuing or continuing statin following intracerebral hemorrhage from the view of a national cohort study.
      ] published in this issue of Atherosclerosis, in which the authors demonstrated that patients with intracerebral hemorrhage (ICH), who continued statin therapy, had better all-cause mortality outcomes compared with those who did not continue statin therapy. Although the authors have some possible explanations for the mechanism via the pleiotropic effect of statins, such as anti-oxidative, BBB protection and anti-inflammation, experimental evidence of continue statin therapy is still lacking. Therefore, we employed an animal model to explore the potential neuroprotective mechanism of continuing statin for ICH.

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      References

        • Chung C.M.
        • Lin M.S.
        • Liu C.H.
        • et al.
        Discontinuing or continuing statin following intracerebral hemorrhage from the view of a national cohort study.
        Atherosclerosis. 2018; 278: 15-22
        • Zhang J.
        • Shi X.
        • Hao N.
        • et al.
        Simvastatin reduces neutrophils infiltration into brain parenchyma after intracerebral hemorrhage via regulating peripheral neutrophils apoptosis.
        Frontiers in Neurosicence. 2018; 12: 977
        • Lattanzi S.
        • Cagnetti C.
        • Provinciali L.
        • et al.
        Neutrophil-to-Lymphocyte ratio predicts the outcome of acute intracerebral hemorrhage.
        Stroke. 2016; 47: 1654-1657
        • Gusdon A.M.
        • Gialdini G.
        • Kone G.
        • et al.
        Neutrophil-lymphocyte ratio and perihematomal edema growth in intracerebral hemorrhage.
        Stroke. 2017; 48: 2589-2592
        • Tao C.
        • Hu X.
        • Wang J.
        • et al.
        Admission neutrophil count and neutrophil to lymphocyte ratio predict 90-day outcome in intracerebral hemorrhage.
        Biomark. Med. 2017; 11: 33-42
        • Wang F.
        • Hu S.
        • Ding Y.
        • et al.
        Neutrophil-to-Lymphocyte ratio and 30-day mortality in patients with acute intracerebral hemorrhage.
        J. Stroke Cerebrovasc. Dis. : the official journal of National Stroke Association. 2016; 25: 182-187
        • Chen Q.
        • Shi X.
        • Tan Q.
        • et al.
        Simvastatin promotes hematoma absorption and reduces hydrocephalus following intraventricular hemorrhage in part by upregulating CD36.
        Translational stroke research. 2017; 8: 362-373
        • Wang Y.
        • Chen Q.
        • Tan Q.
        • et al.
        Simvastatin accelerates hematoma resolution after intracerebral hemorrhage in a PPARgamma-dependent manner.
        Neuropharmacology. 2018; 128: 244-254
        • Lan X.
        • Han X.
        • Li Q.
        • et al.
        Modulators of microglial activation and polarization after intracerebral haemorrhage, Nature reviews.
        Neurology. 2017; 13: 420-433

      Linked Article

      • Discontinuing or continuing statin following intracerebral hemorrhage from the view of a national cohort study
        AtherosclerosisVol. 278
        • Preview
          Statins improve clinical outcomes in patients with ischemic stroke but there is no evidence of the effect of continuing long-term statin therapy in patients with intracerebral hemorrhage (ICH). The aim of this study was to evaluate the impact of continuing statin after ICH.
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      • Reply to: “An update on statins: Pleiotropic effect on intracerebral hemorrhage”
        AtherosclerosisVol. 284
        • Preview
          We thank Chen et al. for their interest in our paper [1]. As several studies reported that statin alleviates inflammation reactions and has an anti-oxidative effect, such benefit is a major component of our hypothesis that statin contributes to mortality reduction after intracerebral hemorrhage (ICH) in our real-world data. The animal model used a similar design of continuing/discontinuing statin as our study did, and the result gave a good laboratory evidence of a pleiotropic effect after ICH. We appreciated the authors’ effort to prove that continuing simvastatin after ICH has a potential neuroprotective effect and promote hematoma resolution in the animal model [2,3].
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