Highlights
- •Carotid intima-media thickness (CIMT) was associated with chronic kidney disease (CKD) in participants with a high CD34+ cell count.
- •No association was observed for participants with a low CD34+ cell count.
- •Endothelial repair activity might determine those associations.
Abstract
Background and aims
Endothelial injury is well-known as a process that can lead to chronic kidney disease
(CKD) and atherosclerosis. Hematopoietic activity is known to be associated inversely
with CKD and positively with atherosclerosis. Since bone-derived progenitor cells
(CD34-positive cells) contribute to endothelial repair (including the progression
of atherosclerosis), understanding the association between CKD and carotid intima-media
thickness (CIMT), in relation to circulating CD34-positive cell count, may be an efficient
means of clarifying the mechanisms underlying endothelial activity.
Methods
We conducted a cross-sectional study of 570 elderly Japanese men aged 60–69 years,
who underwent a general health check-up. Participants were stratified as per a median
circulating CD34-positive cell count (1.01 cells/μL).
Results
Independent of the known cardiovascular risk factors, CIMT was found to be positively
associated with CKD in the participants with high circulating CD34-positive cell counts
but not in participants with low counts. Odds ratios were 1.40 (1.04, 1.89) for participants
with high and 1.01 (0.72, 1.43) for participants with low circulating CD34-positive
cell counts after adjustment for known cardiovascular risk factors at 95% confidence
intervals for CKD with one standard deviation increment of CIMT.
Conclusions
A positive association between CIMT and CKD was observed among participants with high
circulating CD34-positive cell counts but not among participants with low counts.
Endothelial repair activity might determine the association between CKD and CIMT.
Graphical abstract
Graphical Abstract
Keywords
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References
- Impact of chronic kidney disease on carotid atherosclerosis according to blood pressure category: the Suita study.Stroke. 2013; 44: 3537-3539
- Association between renal impairment and anemia in older, rural Japanese men: the Nagasaki Island study.J. Physiol. Anthropol. 2014; 33: 7
- Association between the hemoglobin levels and hypertension in relation to the BMI status in a rural Japanese population: the Nagasaki Islands Study.Intern. Med. 2014; 53: 435-440
- Possible mechanism underlying the association between higher hemoglobin level and hypertension in older Japanese men.Geriatr. Gerontol. Int. 2017; 17: 2586-2592
- Hemoglobin as a possible biochemical index of hypertension-induced vascular damage.J. Physiol. Anthropol. 2016; 35: 4
- Association between hemoglobin levels and arterial stiffness for general Japanese population in relation to body mass index status: the Nagasaki Islands study.Geriatr. Gerontol. Int. 2014; 14: 811-818
- A role for hematopoietic stem cells in promoting angiogenesis.Cell. 2000; 102: 199-209
- Physiological pathway of differentiation of hematopoietic stem cell population into mural cells.J. Exp. Med. 2006; 203: 1055-1065
- Evidence for circulating bone marrow-derived endothelial cells.Blood. 1998; 92: 362-367
- Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells.Circulation. 2008; 117: 206-215
- Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells.FASEB J. 2006; 20 (2559-2261)
- Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels.J. Physiol. Anthropol. 2017; 36: 26
- Triglycerides and blood pressure in relation to circulating CD34-positive cell levels among community-dwelling elderly Japanese men: a cross-sectional study.Environ. Health Prev. Med. 2017; 22: 77
- Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels.Environ. Health Prev. Med. 2018; 23: 16
- Association between height and circulating CD34-positive cells taken into account for the influence of enhanced production among elderly Japanese men: a cross-sectional study.Aging (Albany NY). 2019; 11: 663-672
National Institute of Population and Social Security Research [Home page on the Internet]. [Cited February 14, 2019] Available at http://www.ipss.go.jp/pp-shicyoson/j/shicyoson13/3kekka/Municipalities.asp.
- The ISHAGE guidelines for CD34+ cell determination by flow cytometry. International Society of Hematotherapy and Graft Engineering.J. Hematother. 1996; 5: 213-226
- Prevalence of chronic kidney disease in the Japanese general population.Clin. Exp. Nephrol. 2009; 13: 621-630
- Evaluation of clinical markers of atherosclerosis in young and elderly Japanese adults.Clin. Chem. Lab. Med. 2006; 44: 824-829
- Platelets and circulating CD34-positive cells as an indicator of the activity of the vicious cycle between hypertension and endothelial dysfunction in elderly Japanese men.Atherosclerosis. 2017; 259: 26-31
- Platelets as an indicator of vascular repair in elderly Japanese men.Oncotarget. 2016; 7: 44919-44926
- Airflow obstruction, lung function, and incidence of atrial fibrillation: the Atherosclerosis Risk in Communities (ARIC) study.Circulation. 2014; 129: 971-980
- Endothelial dysfunction.J. Am. Soc. Nephrol. 2004; 15: 1983-1992
- Impact of subclinical carotid atherosclerosis on incident chronic kidney disease in the elderly.Nephrol. Dial. Transplant. 2008; 23: 2593-2598
- Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells.Eur. Heart J. 2009; 30: 584-593
- Platelets, inflammation and atherosclerosis.J. Thromb. Haemostasis. 2007; 5: 203-211
- Height is an indicator of vascular maintenance capacity in older men.Geriatr. Gerontol. Int. 2017; 17: 1729-1736
- Circulating CD34-positive cell, glomerular filtration rate and triglycerides in relation to hypertension.Atherosclerosis. 2015; 243: 71-76
- Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men.Oncotarget. 2018; 0: 7749-7757
Article info
Publication history
Published online: February 11, 2019
Accepted:
February 1,
2019
Received in revised form:
January 30,
2019
Received:
October 30,
2018
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
