Background and Aims: The failure of drugs elevating HDL-C has put in question the role of HDL-C in atheroprotection.
However, the ability of HDL to mediate cholesterol efflux has been associated with
prevalence as well as incidence of cardiovascular disease independent of HDL-C. Stimulation
of Farnesoid X receptor (FXR) by bile acids results in contradictory effects – while
lowering plasma cholesterol (primarily HDL-C ∼-40%) it also increases reverse cholesterol
transport and reduces atherosclerosis in mouse models. The aim of this study was to
investigate the effect of FXR gain- and loss-of-function on HDL composition and function.
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Publication history
Published online: August 03, 2019
EAS19-0342Identification
Copyright
© 2019 Published by Elsevier Inc.
