E-poster session SaaG: Cholesterol efflux and reverse cholesterol transport| Volume 287, e56-e57, August 2019

Treatment With 2-Hydroxypropyl-Β-Cyclodextrin Induces Macrophage Cholesterol Efflux In Vitro But Does Not Induce Lesion Regression In Apoe Knockout Mice In Vivo

      Background and Aims: Macrophage cholesterol efflux is considered a therapeutic target to reduce atherosclerosis susceptibility and induce atherosclerotic lesion regression. 2-hydroxypropyl-β-cyclodextrin (CD) has been suggested to remove cholesterol from cells. In this study, we investigated the effect of CD treatment on macrophage cholesterol efflux in vitro and the ability of established lesions to regress in response to lipid lowering.
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