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99Mtc-Fucoidan As Diagnostic Agent For P-Selectin Imaging: First-In-Human Evaluation (Phase I)

      Background and Aims: Atherosclerosis and thrombosis are characterized by upregulation of P-selectin, an adhesion molecule expressed on activated endothelum and platelets. Therefore, P-selectin represents a promising target for molecular imaging to identify unstable plaques and recurrent thrombosis in patients, for which a clinical unmet need exists. Fucoidan is a polysaccharide ligand extracted from brown algae with nanomolar affinity for P-selectin. We previously demonstrated that 99mTechnetium-labeled (99mTc) Fucoidan selectively targeted P-selectin in animal models of abdominal aortic thrombosis, endocarditis and ischemia-reperfusion. This first-in-human study evaluated the biodistribution and safety of 99mTc-Fucoidan in healthy volunteers.
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