99Mtc-Fucoidan As Diagnostic Agent For P-Selectin Imaging: First-In-Human Evaluation (Phase I)

      Background and Aims: Atherosclerosis and thrombosis are characterized by upregulation of P-selectin, an adhesion molecule expressed on activated endothelum and platelets. Therefore, P-selectin represents a promising target for molecular imaging to identify unstable plaques and recurrent thrombosis in patients, for which a clinical unmet need exists. Fucoidan is a polysaccharide ligand extracted from brown algae with nanomolar affinity for P-selectin. We previously demonstrated that 99mTechnetium-labeled (99mTc) Fucoidan selectively targeted P-selectin in animal models of abdominal aortic thrombosis, endocarditis and ischemia-reperfusion. This first-in-human study evaluated the biodistribution and safety of 99mTc-Fucoidan in healthy volunteers.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect