Background and Aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are reported to degrade LDL receptors and thereby prevent hypercholesterolemia. Thus, regulation of PCSK9 levels might prevent the onset of dislipidemia. However, little is known if food ingredients can regulate circulating PCSK9 levels. D-Allulose, an epimer of D-fructose, is one of rare sugars and is a non-caloric sweetener having several health benefits, including suppression of increased serum glucose levels and fat accumulation. However, the effects of D-allulose on cholesterol metabolism are unclear. Here, we examined the effects of D-allulose on PCSK9 levels and cholesterol metabolism in Golden Syrian hamsters.
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Published online: August 05, 2019EAS19-0578
© 2019 Published by Elsevier Inc.