Posters 26 - 29 May, 2019 03. Lipids - 03.06 Cholesterol efflux and reverse cholesterol transport| Volume 287, e222, August 2019

The Role Of Effector Proteins In Cellular Cholesterol Efflux

      Background and Aims: High-density lipoprotein (HDL) plays a key role in metabolism of cholesterol through a mechanism known as reverse cholesterol transport (RCT). Cellular cholesterol efflux is thought to represent a first step of RCT. In the previous study, we determined, applying a transcriptome analysis and bioinformatics approach, that the expression of several genes (CCL4, INSIG1, LDLR) was specifically modified in monocyte-derived human macrophages exposed to HDL. In this study, we evaluated involvement of CCL4, INSIG1 and LDLR genes in cellular cholesterol efflux mediated by HDL.
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