Background and Aims: High-density lipoprotein (HDL) plays a key role in metabolism of cholesterol through
a mechanism known as reverse cholesterol transport (RCT). Cellular cholesterol efflux
is thought to represent a first step of RCT. In the previous study, we determined,
applying a transcriptome analysis and bioinformatics approach, that the expression
of several genes (CCL4, INSIG1, LDLR) was specifically modified in monocyte-derived human macrophages exposed to HDL.
In this study, we evaluated involvement of CCL4, INSIG1 and LDLR genes in cellular cholesterol efflux mediated by HDL.
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Publication history
Published online: August 05, 2019
EAS19-0159Identification
Copyright
© 2019 Published by Elsevier Inc.
