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Posters 26 - 29 May, 2019 02. Inflammation, immunity and macrophages - 02.02 Macrophages in lipid metabolism and atherosclerosis| Volume 287, e239, August 2019

Eicosapentaenoic Acid (Epa) Differentially Affects Abca1-Mediated Cholesterol Efflux From Primary Human Macrophages Or Thp-1 Cell Line

  • N. Fournier
    Affiliations
    Faculte de Pharmacie- Universite Paris Sud - Paris Saclay, LipSys2 EA 7357- equipe "macrophages- cholesterol and atherosclerosis", Chatenay-Malabry, France

    Hopital Europeen Georges Pompidou, AP-HP, Laboratoire de Biochimie, Paris, France
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  • H. Dakroub
    Affiliations
    Faculte de Pharmacie- Universite Paris Sud - Paris Saclay, LipSys2 EA 7357- equipe "macrophages- cholesterol and atherosclerosis", Chatenay-Malabry, France
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  • J.F. Benoist
    Affiliations
    Hopital Robert Debre, AP-HP, Laboratoire de Biochimie Hormonologie, Paris, France
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  • F. Allaoui
    Affiliations
    Faculte de Pharmacie- Universite Paris Sud - Paris Saclay, LipSys2 EA 7357- equipe "macrophages- cholesterol and atherosclerosis", Chatenay-Malabry, France
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  • G. Sayet
    Affiliations
    Faculte de Pharmacie- Universite Paris Sud - Paris Saclay, LipSys2 EA 7357, equipe "chimie analytique pharmaceutique", Chatenay-Malabry, France
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  • J.L. Paul
    Affiliations
    Faculte de Pharmacie- Universite Paris Sud - Paris Saclay, LipSys2 EA 7357- equipe "macrophages- cholesterol and atherosclerosis", Chatenay-Malabry, France

    Hopital Europeen Georges Pompidou, AP-HP, Laboratoire de Biochimie, Paris, France
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      Background and Aims: A diet rich in n-3 polyunsaturated fatty acids (PUFAs), especially in eicosapentaenoic acid (EPA, C20:5 n-3) is cardioprotective. PUFAs modulate cellular eicosanoids formed from arachidonic acid (AA, C20:4 n-6) and EPA. We investigated the impact of EPA supplementation on ABCA1-mediated cholesterol efflux, an antiatherogenic pathway.
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