Posters 26 - 29 May, 2019 01. Atherosclerosis and vascular biology - 01.05 Smooth muscle cells| Volume 287, e259, August 2019

Hmgb1 Enhances Rage Expression Via 5-Lipoxygenase Signaling Leading To An Increase In Age-Mediated Proliferation Of Vascular Smooth Muscle Cells

      Background and Aims: Receptors for advanced glycation end-product (RAGE) play a pivotal role in the progression of vascular remodeling in the injured vasculatures. However, the precise mechanisms regulating RAGE expression in VSMCs is unclear. Given the importance of 5-lipoxygenase (5-LO)-derived mediators in vascular injury, this study aimed to determine RAGE expression in VSMCs exposed to HMGB1, and also investigated the role of 5-LO signaling in HMGB1-induced RAGE expression and AGE-induced VSMC proliferation.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect