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Posters 26 - 29 May, 2019 01. Atherosclerosis and vascular biology - 01.05 Smooth muscle cells| Volume 287, e259, August 2019

Hmgb1 Enhances Rage Expression Via 5-Lipoxygenase Signaling Leading To An Increase In Age-Mediated Proliferation Of Vascular Smooth Muscle Cells

Published:August 05, 2019DOI:https://doi.org/10.1016/j.atherosclerosis.2019.06.799
Hmgb1 Enhances Rage Expression Via 5-Lipoxygenase Signaling Leading To An Increase In Age-Mediated Proliferation Of Vascular Smooth Muscle Cells
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      Background and Aims: Receptors for advanced glycation end-product (RAGE) play a pivotal role in the progression of vascular remodeling in the injured vasculatures. However, the precise mechanisms regulating RAGE expression in VSMCs is unclear. Given the importance of 5-lipoxygenase (5-LO)-derived mediators in vascular injury, this study aimed to determine RAGE expression in VSMCs exposed to HMGB1, and also investigated the role of 5-LO signaling in HMGB1-induced RAGE expression and AGE-induced VSMC proliferation.
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      Article info

      Publication history

      Published online: August 05, 2019
      EAS19-0886

      Identification

      DOI: https://doi.org/10.1016/j.atherosclerosis.2019.06.799

      Copyright

      © 2019 Published by Elsevier Inc.

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