Background and Aims: In aortic stenosis (AS), valvular calcification causes the aortic valve dysfunction. Currently, no pharmacologic treatment is available for AS. Vitamin K dependent Matrix Gla protein is known to inhibit vascular calcification in mice and recently, in the small interventional proof of concept study in patients, vitamin K attenuated the progression of AS. Here, we studied the effect of menaquinone 4 (MK4) on valvular calcification in the hypercholesterolemic mouse model of AS.
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Published online: August 05, 2019EAS19-0670
© 2019 Published by Elsevier Inc.