Background and Aims: Interleukin-11 (IL-11) is a stromal cell derived cytokine, highly expressed by smooth muscle cells (SMCs), heart, skin and testis. Beyond its known role in stimulating the maturation of megakaryocytes, it also exerts anti-inflammatory effects in T-cells and macrophages. Our preliminary observations indicated that both high-density lipoproteins (HDL) and sphingosine 1-phosphate (S1P) dose dependently induce IL-11 production in SMCs, via S1P2 receptor stimulation. Since HDL-S1P showed anti-atherogenic potential, we investigated the effects of exogenous administration of IL-11 to athero-prone mouse models and in vitro.
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Published online: August 05, 2019EAS19-1121
© 2019 Published by Elsevier Inc.