Posters 26 - 29 May, 2019 07. Late Breaking| Volume 287, e283, August 2019

Interleukin-11: A Neglected Cytokine With Anti-Atherogenic Properties?

      Background and Aims: Interleukin-11 (IL-11) is a stromal cell derived cytokine, highly expressed by smooth muscle cells (SMCs), heart, skin and testis. Beyond its known role in stimulating the maturation of megakaryocytes, it also exerts anti-inflammatory effects in T-cells and macrophages. Our preliminary observations indicated that both high-density lipoproteins (HDL) and sphingosine 1-phosphate (S1P) dose dependently induce IL-11 production in SMCs, via S1P2 receptor stimulation. Since HDL-S1P showed anti-atherogenic potential, we investigated the effects of exogenous administration of IL-11 to athero-prone mouse models and in vitro.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect