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Serum lipoprotein (a) is associated with increased risk of stroke in Chinese adults: A prospective study

  • Author Footnotes
    1 These authors contributed equally to this work.
    Jie Zhang
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital North, Shanghai Jiao-Tong University School of Medicine, 999 Xi Wang Road, Shanghai, 201801, China

    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Rui Du
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Kui Peng
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
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  • Xueyan Wu
    Affiliations
    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
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  • Chunyan Hu
    Affiliations
    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
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  • Mian Li
    Affiliations
    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
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  • Yu Xu
    Affiliations
    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
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  • Min Xu
    Affiliations
    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
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  • Shuangyuan Wang
    Affiliations
    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
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  • Yufang Bi
    Affiliations
    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
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  • Weiqing Wang
    Affiliations
    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
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  • Jieli Lu
    Correspondence
    Corresponding author.
    Affiliations
    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
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  • Yuhong Chen
    Correspondence
    Corresponding author. Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital North, Shanghai Jiao-Tong University School of Medicine, 999 Xi Wang Road, Shanghai, 201801, China.
    Affiliations
    Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital North, Shanghai Jiao-Tong University School of Medicine, 999 Xi Wang Road, Shanghai, 201801, China

    National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work.

      Highlights

      • The 5.1-year incidence of stroke was higher in participants with elevated serum Lp (a).
      • Participants with higher serum Lp (a) levels had lower event-free survival rate in this Chinese population.
      • Serum Lp (a) is associated with increased risk of incident stroke in this Chinese population.

      Abstract

      Background and aims

      Epidemiological evidence on the association between elevated lipoprotein (a) (Lp (a)) with risk of stroke remains inconsistent. We aimed to investigate the association between serum Lp (a) level and the risk of stroke among middle-aged and elderly Chinese.

      Methods

      A community-based prospective cohort study of 8500 participants aged 40 years or older was conducted in Jiading district, Shanghai, China, in 2010. The incident strokes were documented at follow-up visit during 2014–2015.

      Results

      During a mean follow-up of 5.1 years, 444 incident cases of stroke occurred. The incidences of stroke were 4.44%, 5.14% and 6.14% from the lowest to the highest serum Lp (a) tertile, respectively. A significant association between serum Lp (a) tertile and the risk of incident stroke was observed (p for trend<0.05). Compared with individuals in the lowest tertile of serum Lp (a), the multivariable adjusted hazards ratio (HR) and 95% confidence interval (CI) for incident stroke in Lp (a) tertile 3 were 1.34 (1.06–1.70).

      Conclusions

      Serum Lp (a) concentration was associated with increased risk of incident stroke in Chinese adults.

      Graphical abstract

      Keywords

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