The Hydra of Lerna is a serpentine water monster in Greek mythology. The Hydra possessed many heads that had an enormous regenerative capacity: whenever a head was cut off, the Hydra would regrow two heads. Thus, it was not easy for the ancient hero Herakles to win against this constantly regenerating problem.
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- Lipoprotein(a) - resurrected by genetics.J. Intern. Med. 2013; 273: 6-30
- Apo(a) isoforms predict risk for coronary heart disease: a study in six populations.Arterioscler. Thromb. 1992; 12: 1214-1226
- Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis.Lancet Diabetes Endocrinol. 2017; 5: 524-533
- Genetically elevated lipoprotein(a) and increased risk of myocardial infarction.J. Am. Med. Assoc. 2009; 301: 2331-2339
- Immunochemical quantification of human plasma Lp(a) lipoprotein.Lipids. 1974; 9: 15-26
- NHLBI working group recommendations to reduce lipoprotein(a)-mediated risk of cardiovascular disease and aortic stenosis.J. Am. Coll. Cardiol. 2018; 71: 177-192
- Lipoprotein(a)-cholesterol levels estimated by vertical auto profile correlate poorly with Lp(a) mass in hyperlipidemic subjects: implications for clinical practice interpretation of Lp(a)-mediated risk.J. Clin. Lipidol. 2016; 10: 1389-1396
- Lipoprotein(a) levels, apo(a) isoform size, and coronary heart disease risk in the framingham offspring study.J. Lipid Res. 2011; 52: 1181-1187
- Comparison of lipoprotein(a) serum concentrations measured by six commercially available immunoassays.Atherosclerosis. 2019; : 206-213
- The mysteries of lipoprotein(a).Science. 1989; 246: 904-910
- Effect of the number of apolipoprotein(a) kringle 4 domains on immunochemical measurements of lipoprotein(a).Clin. Chem. 1995; 41: 246-255
- A comprehensive map of single base polymorphisms in the hypervariable LPA Kringle IV-2 copy number variation region.J. Lipid Res. 2019; 60: 186-199
- Simultaneous quantitation and size characterization of apolipoprotein(a) by ultra-performance liquid chromatography/mass spectrometry.Rapid Commun. Mass Spectrom. 2014; 28: 1101-1106
- Relationship of lipoprotein(a) molar concentrations and mass according to lipoprotein(a) thresholds and apolipoprotein(a) isoform size.J. Clin. Lipidol. 2018; 12: 1313-1323
- Variation in lipoprotein(a) concentration associated with different apolipoprotein(a) alleles.J. Clin. Investig. 1994; 93: 1481-1492
- A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction.Eur. Heart J. 2017; 38: 1823-1831
- Prediction of cardiovascular risk by Lp(a) concentrations or genetic variants within the LPA gene region.Clin. Res. Cardiol. Suppl. 2019; 14: 5-12
- Lipoprotein(a) and oxidized phospholipids promote valve calcification in patients with aortic stenosis.J. Am. Coll. Cardiol. 2019; 73: 2150-2162
- Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials.Lancet. 2016; 388: 2239-2253
Kronenberg F. Therapeutic lowering of lipoprotein(a): how much is enough?, Atherosclerosis: doi: 10.1016/j.atherosclerosis.2019.07.003 (in press).
Published online: August 31, 2019
Accepted: August 29, 2019
Received: August 23, 2019
© 2019 Elsevier B.V. All rights reserved.
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- Comparison of lipoprotein (a) serum concentrations measured by six commercially available immunoassaysAtherosclerosisVol. 289
- PreviewLipoprotein (a) [Lp(a)] is an established causal risk factor for cardiovascular disease (CVD), independently of low-density lipoproteins (LDL) and other risk factors. The recognition of Lp(a) as an atherogenic molecule has raised the demand for reliable quantification methods in the clinical laboratory. The aim of this work is to compare commercial immunochemical assays.