- •Asymptomatic individuals with LDL-C ≥190 mg/dL are considered high-risk for future cardiovascular events.
- •Distribution of risk factors in these individuals is heterogeneous and varies by the presence or absence of CAC.
- •In MESA participants with LDL-C ≥190 mg/dL, younger age, female sex, and lack of diabetes were associated with absence of CAC.
- •Absence of CAC was independently associated with better cardiovascular outcomes in this MESA sub-group.
- •Absence of CAC may help ‘de-risk’ individuals in this high-risk patient population.
Background and aims
Abbreviations:ASCVD (atherosclerotic cardiovascular disease), CAC (coronary artery calcium), CHD (coronary heart disease), Hs-CRP (high-sensitivity C-reactive protein), MESA (Multi-Ethnic Study of Atherosclerosis), RR (relative risk)
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