Highlights
- •We studied the influence of regular alcohol intake, physical activity and smoking habit modulating PPT in the CORDIOPREV study.
- •PPT and the prevalence of undesirable response was evaluate in each subgroups. We assessed the main determinants risk factors in the presence of undesirable response.
- •Smoking is an independent risk factor modulating the magnitude of PPT.
- •After tobacco cessation, in long-term ex-smokers, PPT progressively decreases to similar magnitude to never smokers.
- •No differences observed in the magnitude of PPT according to regular physical activity or alcohol intake habits.
Abstract
Background and aims
Recent evidence suggests that postprandial hypertriglyceridemia (PPT) is associated
with the incidence of CVD. Several non-modifiable factors (genetics, age, gender)
and lifestyle factors (physical activity, smoking, regular alcohol) have shown their
ability to modulate PPT. We evaluate the influence of regular alcohol intake, physical
activity and smoking habit modulating PPT in the CORDIOPREV study (NCT00924937).
Methods
1002 patients were subject to an oral fat load test meal and serial blood samples
were drawn at 0, 1, 2, 3 and 4 h during postprandial state. A PPT concentration above
2.5 mmol/L (220 mg/dL) at any time point has been established as a detrimental response.
Alcohol consumption was defined as non-drinkers, moderate and severe intake; regular
physical activity exceeding than or lower than 1000 MET/week; smoking habit was classified
in current, never, recent ex-smokers and long-term ex-smokers.
Results
The prevalence of undesirable PPT response was 68% in current, 58% in recent ex-smokers,
49% in long-term ex-smokers and 48% in never smokers (p < 0.001). Current and recent ex-smokers displayed higher PPT response as well as
a greater area under the curve (AUC) and higher incremental (iAUC) of triglycerides
(TG) compared with long-term ex-smokers and never smokers (p < 0.05), without differences among these subgroups. No differences were observed
in the magnitude of PPT according to regular physical activity or alcohol intake habits.
Conclusions
Smoking is an independent risk factor modulating the magnitude of PPT. However, after
tobacco cessation, ex-smokers show a progressive decrease on their PPT to reach levels
similar to those of never smokers.
Graphical abstract
Graphical Abstract
Keywords
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References
- Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017.Lancet. 2018; 392: 1736-1788
- Metabolic and lifestyle determinants of postprandial lipemia differ from those of fasting triglycerides: the Atherosclerosis Risk in Communities (ARIC) study.Arterioscler. Thromb. Vasc. Biol. 2001; 21: 275-281
- Triglyceride-rich lipoproteins and atherosclerosis, from fast to feast.Ann. Med. 1993; 25: 431-435
- Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women.Jama. 2007; 298: 309-316
- Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism.Br. J. Nutr. 2007; 98: 458-473
- Acute resistance exercise attenuates fasting and postprandial triglyceridemia in women by reducing triglyceride concentrations in triglyceride-rich lipoproteins.Eur. J. Appl. Physiol. 2010; 110: 869-874
- Alcohol and J-shaped curves.Alcohol Clin. Exp. Res. 1998; 22 (359S-64S)
- The effect of chronic tobacco smoking and chewing on the lipid profile.J. Clin. Diagn. Res. J. Clin. Diagn. Res. 2013; 7: 31-34
- CORonary Diet Intervention with Olive oil and cardiovascular PREVention study (the CORDIOPREV study): rationale, methods, and baseline characteristics: a clinical trial comparing the efficacy of a Mediterranean diet rich in olive oil versus a low-fat diet on cardiovascular disease in coronary patients.Am. Heart J. 2016; 177: 42-50
- WHO Report on the Global Tobacco Epidemic, 2017: Monitoring Tobacco Use and Prevention Policies. World Health Organization, Geneva2017 (Licence: CC BY-NC-SA 30 IGO. 2017)
- The impact of passive and active smoking on inflammation, lipid profile and the risk of myocardial infarction.Open Heart. 2017; 4e000620
- The physical activity Guidelines for Americans.Jama. 2018; 320: 2020-2028
- The ABC of physical activity for health: a consensus statement from the British association of sport and exercise sciences.J. Sport. Sci. 2010; 28: 573-591
- Screening and behavioral counseling interventions in primary care to reduce alcohol misuse: U.S. preventive services task force recommendation statement.Ann. Intern. Med. 2013; 159: 210-218
- Long-term consumption of a Mediterranean diet improves postprandial lipemia in patients with type 2 diabetes: the Cordioprev randomized trial.Am. J. Clin. Nutr. 2018; 108: 963-970
- Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis.Curr. Vasc. Pharmacol. 2011; 9: 271-280
- Smoking, inflammatory patterns and postprandial hypertriglyceridemia.Atherosclerosis. 2009; 203: 633-639
- Epidemiology of smoking-induced cardiovascular disease.Prog. Cardiovasc. Dis. 2003; 46: 11-29
- Risk of cardiovascular disease from cumulative cigarette use and the impact of smoking intensity.Epidemiology. 2016; 27: 395-404
- Postprandial triglycerides and endothelial function.Exp. Clin. Endocrinol. Diabetes. 2001; 109 (official journal, German Society of Endocrinology [and] German Diabetes Association): S533-S547
- Cigarette smoking, endothelial injury and cardiovascular disease.Int. J. Exp. Pathol. 2000; 81: 219-230
- Fibrinogen, cigarette smoking, and risk of cardiovascular disease: insights from the Framingham Study.Am. Heart J. 1987; 113: 1006-1010
- Nitric oxide and atherosclerosis.Nitric Oxide Biol. Chem. 2001; 5: 88-97
- Smoking intensity and lipoprotein abnormalities in active smokers.J. Clin. Lipidol. 2009; 3: 372-378
- Clinical characteristics and prognosis of acute myocardial infarction in young smokers and non-smokers (</= 45 years): a systematic review and meta-analysis.Oncotarget. 2017; 8: 81195-81203
- Smoking cessation and outcome after ischemic stroke or TIA.Neurology. 2017; 89: 1723-1729
- Ischaemic stroke.Eur. J. Neurol. 2018; 25: 35-40
- Postprandial lipemia: factoring in lipemic response for ranking foods for their healthiness.Lipids Health Dis. 2017; 16: 178
- Postprandial elevation of ApoB-48-containing triglyceride-rich particles and retinyl esters in normolipemic males who smoke.Arterioscler. Thromb. Vasc. Biol. 1997; 17: 2096-2102
- The insulin resistance syndrome and postprandial lipid intolerance in smokers.Atherosclerosis. 1997; 129: 79-88
- Regression of postprandial lipemia after smoking cessation.J. Am. Coll. Cardiol. 1996; 27
- Second i2b2 workshop on natural language processing challenges for clinical records.Proc. Annu. Symp. AMIA. 2008; : 1252-1253
- Identifying patient smoking status from medical discharge records.J. Am. Med. Inform. Assoc. : JAMIA. 2008; 15: 14-24
- Smoking status effect on inflammatory markers in a randomized trial of current and former heavy smokers.Int. J. Inflamm. 2015; 2015: 439396
- Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community.Circulation. 2010; 122: 1470-1477
- Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).Circulation. 2000; 102: 42-47
- C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women.N. Engl. J. Med. 2000; 342: 836-843
- Effects of smoking intensity and cessation on inflammatory markers in a large cohort of active smokers.Am. Heart J. 2010; 160: 458-463
- Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation.Nutr. Rev. 2017; 75: 307-326
- Moderate alcohol consumption and triglyceridemia.Physiol. Res. 2015; 64: S371-S375
- Effects of aerobic exercise on lipids and lipoproteins.Lipids Health Dis. 2017; 16: 132
- Postprandial lipemic and inflammatory responses to high-fat meals: a review of the roles of acute and chronic exercise.Nutr. Metab. 2016; 13: 80
Article info
Publication history
Published online: September 28, 2019
Accepted:
September 27,
2019
Received in revised form:
September 13,
2019
Received:
March 11,
2019
Identification
Copyright
© 2019 Published by Elsevier B.V.
