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Lifestyle factors modulate postprandial hypertriglyceridemia: From the CORDIOPREV study

  • Author Footnotes
    1 These authors contributed equally to this work.
    Ana Leon-Acuña
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Jose D. Torres-Peña
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
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  • Juan F. Alcala-Diaz
    Affiliations
    Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
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  • Cristina Vals-Delgado
    Affiliations
    Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
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  • Irene Roncero-Ramos
    Affiliations
    Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
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  • Elena Yubero-Serrano
    Affiliations
    Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
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  • Francisco J. Tinahones
    Affiliations
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain

    Endocrinology and Nutrition Unit, Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria University Hospital, Malaga, Spain
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  • Manuel Castro-Clerico
    Affiliations
    Biochemistry Laboratory and Reina Sofia University Hospital, Cordoba, Spain
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  • Javier Delgado-Lista
    Affiliations
    Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
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  • Jose M. Ordovas
    Affiliations
    Nutrition and Genomics Laboratory, J.M.-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA

    IMDEA Alimentación, Madrid, Spain

    CNIC, Madrid, Spain
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Jose Lopez-Miranda
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work.
    Pablo Perez-Martinez
    Correspondence
    Corresponding author. Reina Sofia University Hospital, Lipids and Atherosclerosis Research Unit, Avda. Menéndez Pidal, s/n. 14004, Córdoba, Spain.
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work.

      Highlights

      • We studied the influence of regular alcohol intake, physical activity and smoking habit modulating PPT in the CORDIOPREV study.
      • PPT and the prevalence of undesirable response was evaluate in each subgroups. We assessed the main determinants risk factors in the presence of undesirable response.
      • Smoking is an independent risk factor modulating the magnitude of PPT.
      • After tobacco cessation, in long-term ex-smokers, PPT progressively decreases to similar magnitude to never smokers.
      • No differences observed in the magnitude of PPT according to regular physical activity or alcohol intake habits.

      Abstract

      Background and aims

      Recent evidence suggests that postprandial hypertriglyceridemia (PPT) is associated with the incidence of CVD. Several non-modifiable factors (genetics, age, gender) and lifestyle factors (physical activity, smoking, regular alcohol) have shown their ability to modulate PPT. We evaluate the influence of regular alcohol intake, physical activity and smoking habit modulating PPT in the CORDIOPREV study (NCT00924937).

      Methods

      1002 patients were subject to an oral fat load test meal and serial blood samples were drawn at 0, 1, 2, 3 and 4 h during postprandial state. A PPT concentration above 2.5 mmol/L (220 mg/dL) at any time point has been established as a detrimental response. Alcohol consumption was defined as non-drinkers, moderate and severe intake; regular physical activity exceeding than or lower than 1000 MET/week; smoking habit was classified in current, never, recent ex-smokers and long-term ex-smokers.

      Results

      The prevalence of undesirable PPT response was 68% in current, 58% in recent ex-smokers, 49% in long-term ex-smokers and 48% in never smokers (p < 0.001). Current and recent ex-smokers displayed higher PPT response as well as a greater area under the curve (AUC) and higher incremental (iAUC) of triglycerides (TG) compared with long-term ex-smokers and never smokers (p < 0.05), without differences among these subgroups. No differences were observed in the magnitude of PPT according to regular physical activity or alcohol intake habits.

      Conclusions

      Smoking is an independent risk factor modulating the magnitude of PPT. However, after tobacco cessation, ex-smokers show a progressive decrease on their PPT to reach levels similar to those of never smokers.

      Graphical abstract

      Keywords

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