Electronic cigarettes, or e-cigarettes, are rapidly gaining their shares in the tobacco
market. Not only are they marketed as a less harmful alternative to regular tobacco
products, they are also gaining a reputation as fashionable life-style accessories.
Nevertheless, voices from diverse scientific and societal areas raise concerns about
the supposed “benevolence” of e-cigarettes. For example, e-cigarettes may reduce the
perception especially of adolescents to the harm of smoking [
[1]
]. In this line, a recent meta-analysis found that e-cigarette users are at a higher
risk to continue consuming regular tobacco products on the longer term [
[2]
].Keywords
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References
- E-cigarette adverts and children's perceptions of tobacco smoking harms: an experimental study and meta-analysis.BMJ Open. 2018; 8e020247
- Association between initial use of e-cigarettes and subsequent cigarette smoking among adolescents and young adults: a systematic review and meta-analysis.JAMA Pediatr. 2017; 171: 788-797
- Electronic cigarette smoking increases aortic stiffness and blood pressure in young smokers.J. Am. Coll. Cardiol. 2016; 67: 2802-2803
- Acute effects of electronic cigarette inhalation on the vasculature and the conducting airways.Cardiovasc. Toxicol. 2019; 19: 441-450
- Angiogenic activity of nicotinic acetylcholine receptors: implications in tobacco-related vascular diseases.Pharmacol. Ther. 2009; 121: 205-223
- Arteriovenous differences in plasma concentration of nicotine and catecholamines and related cardiovascular effects after smoking, nicotine nasal spray, and intravenous nicotine.Clin. Pharmacol. Ther. 1997; 62: 453-463
- Nicotine strongly activates dendritic cell-mediated adaptive immunity: potential role for progression of atherosclerotic lesions.Circulation. 2003; 107: 604-611
- The role of nicotine in the pathogenesis of atherosclerosis.Atherosclerosis. 2011; 215: 281-283
- Human platelets express functional alpha7-nicotinic acetylcholine receptors.Arterioscler. Thromb. Vasc. Biol. 2011; 31: 928-934
- Effects of nicotine, its metabolites and tobacco extracts on human platelet function in vitro.Toxicol. Vitro. 2013; 27: 932-938
- Regulation of E-selectin, P-selectin, and intercellular adhesion molecule 1 expression in mouse cremaster muscle vasculature.Microcirculation. 1997; 4: 311-319
- The life cycle of platelet granules.F1000Res. 2018; 7: 236
- Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration.J. Thromb. Haemostasis. 2014; 12: 614-627
- Extracellular vesicles from activated platelets: a semiquantitative cryo-electron microscopy and immuno-gold labeling study.Platelets. 2017; 28: 263-271
- Single-step isolation of extracellular vesicles by size-exclusion chromatography.J. Extracell. Vesicles. 2014; 3https://doi.org/10.3402/jev.v3.23430
- Extracellular vesicles released in response to respiratory exposures: implications for chronic disease.J. Toxicol. Environ. Health B Crit. Rev. 2018; 21: 142-160
- Persistence of circulating endothelial microparticles in COPD despite smoking cessation.Thorax. 2016; 71: 1137-1144
- Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium.Arterioscler. Thromb. Vasc. Biol. 2005; 25: 1512-1518
- Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype.J. Extracell. Vesicles. 2017; 61322454
- Microparticles from apoptotic platelets promote resident macrophage differentiation.Cell Death Dis. 2011; 2: e211
- Role of platelet-derived microvesicles as crosstalk mediators in atherothrombosis and future pharmacology targets: a link between inflammation, atherosclerosis, and thrombosis.Front. Pharmacol. 2016; 7: 293
- Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles.J. Extracell. Vesicles. 2019; 81585163
- Clinical significance of tissue factor-exposing microparticles in arterial and venous thrombosis.Semin. Thromb. Hemost. 2015; 41: 718-727
- Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers.Atherosclerosis. 2020; 301 (in press): 93-100
Article info
Publication history
Published online: March 27, 2020
Accepted:
March 18,
2020
Received in revised form:
March 11,
2020
Received:
March 5,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
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- Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteersAtherosclerosisVol. 301
- PreviewE-cigarette use is increasingly common. Whether e-cigarettes are harmful to human health is an intensely debated subject. In order to investigate whether e-cigarettes with and without nicotine cause different vascular responses, we obtained blood samples from healthy young volunteers who performed brief active e-cigarette inhalations. Extracellular vesicles (EVs) of endothelial and platelet origin were measured to determine vascular changes.
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