Abstract| Volume 315, e12, December 2020

Sphingosine 1-phosphate (S1P) receptor type 1 signaling induces an anti-atherogenic phenotype in macrophages and attenuates atherosclerosis in LDL-receptor-deficient mice

      Background and Aims: Sphingosine 1-phosphate (S1P) accounts for antiatherogenic properties of high-density lipoproteins, but the S1P receptor subtype mediating the atheroprotective effects of S1P and the underlying molecular mechanisms remain enigmatic. Experimental models engineered to amplify the signaling of endogenous S1P over its specific receptors may help in clarifying this issue. To this purpose, we generated a mouse model overexpressing S1P receptor type 1 (S1P1) specifically in the myeloid compartment and studied the effect on atherosclerosis development.
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