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Abstract| Volume 315, e85-e86, December 2020

Intermittent fasting reduces hypertriglyceridemia and protects against atherosclerosis progression in males and females APOE-/- mice, only under chow diet

  • S. Najib
    Affiliations
    Institut national de la santé et de la recherche médicale, INSERM, Institute Of Cardiovascular And Metabolic Diseases (i2mc) Inserm/ups Umr1048, Toulouse Cedex, France
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  • C. Trenteseaux
    Affiliations
    Institut national de la santé et de la recherche médicale, INSERM, Institute Of Cardiovascular And Metabolic Diseases (i2mc) Inserm/ups Umr1048, Toulouse Cedex, France
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  • J. Merian
    Affiliations
    Institut national de la santé et de la recherche médicale, INSERM, Institute Of Cardiovascular And Metabolic Diseases (i2mc) Inserm/ups Umr1048, Toulouse Cedex, France
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  • G. Combes
    Affiliations
    Institut national de la santé et de la recherche médicale, INSERM, Institute Of Cardiovascular And Metabolic Diseases (i2mc) Inserm/ups Umr1048, Toulouse Cedex, France
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  • T. Duparc
    Affiliations
    Institut national de la santé et de la recherche médicale, INSERM, Institute Of Cardiovascular And Metabolic Diseases (i2mc) Inserm/ups Umr1048, Toulouse Cedex, France
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  • D. Beuzelin
    Affiliations
    Institut national de la santé et de la recherche médicale, INSERM, Institute Of Cardiovascular And Metabolic Diseases (i2mc) Inserm/ups Umr1048, Toulouse Cedex, France
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  • L. Martinez
    Affiliations
    Institut national de la santé et de la recherche médicale, INSERM, Institute Of Cardiovascular And Metabolic Diseases (i2mc) Inserm/ups Umr1048, Toulouse Cedex, France
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  • L. Ghezali
    Affiliations
    Institut national de la santé et de la recherche médicale, INSERM, Institute Of Cardiovascular And Metabolic Diseases (i2mc) Inserm/ups Umr1048, Toulouse Cedex, France
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      Background and Aims: Intermittent fasting (IF) has been shown to produce beneficial health effects. Preventing atherosclerosis with IF is promising, yet its therapeutic applicability against preexisting atherosclerosis, diverse nutritional challenges, and gender is unknown. We thus investigated the impact of IF on atherosclerosis development in either males or females apolipoprotein E knockout (apoE-/-) mice fed chow (CD) or high fat (HFD) diet.
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