Abstract| Volume 315, e151, December 2020

Cardiovascular events, LDL and HDL subfraction size in a cohort of FH patients

      Background and Aims: Familial Hypercholesterolemia (FH) is a genetic disease characterized by premature Arteriosclerotic Cardiovascular Disease (ASCVD). Low Density Lipoproteins (LDLs) may be subdivided into two main fractions: large-buoyant (lbLDL) and small-dense (sdLDL) particles, with different metabolic behaviour and atherogenicity. In a similar manner High Density Lipoproteins (HDLs) may be separated into subpopulations of different size and composition. Aim of the present study is the evaluation of LDL and HDL subfractions in FH patients, tring to identify their predicting value in cardiovascular disease onset and the effects of lipid-lowering treatment.
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