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“Plaque erosion” or the danger of eerily quiet appearance

  • Giuseppina Caligiuri
    Correspondence
    Corresponding author.
    Affiliations
    Université de Paris, Laboratory for Vascular Translational Science, Inserm U1148, F-75018, Paris, France
    Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Nord Val-de-Seine, Site Bichat, Paris, France
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  • Ziad Mallat
    Affiliations
    Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK
    Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, Paris, France
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      The characteristic histopathological features of “plaque erosion” have been extensively unveiled ever since its first description more than 20 years ago [
      • Farb A.
      • Burke A.P.
      • Tang A.L.
      • Liang T.Y.
      • Mannan P.
      • Smialek J.
      • Virmani R.
      Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death.
      ]. Since then, the interest of both fundamental and clinical scientists working in atherosclerosis has kept rising, as reflected by the ever-growing number of articles published in this field. Yet, the effective impact of this entity, as well as its underlying mechanisms, has remained largely elusive due to the lack of specific imaging modalities and diagnostic tests, and the lack of appropriate experimental models.

      Keywords:

      Atherosclerosis (Plaque erosion), Thrombosis (Mechanisms)
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