Creation of cybrid culture with mtDNA mutation M.14846G>A

      Background and Aims: Cytoplasmatic hybrids (cybrids) are widely used in scientific researches as a cell model for investigating different human diseases. The aim of the present study was creation of cybrid lines with mtDNA mutation m.14846G>A. In our preliminary studies, it was found that, after reaching the threshold level of heteroplasmy, mutation m.14846G>A had a protective effect in atherosclerosis (17.5%).
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