Background and Aims: Cardiovascular disease (CVD), the leading cause of mortality in industrially developed
countries, is primarily caused by atherosclerosis, characterized by an abnormal lipid
and inflammatory cell accumulation in the intima, which is associated with atheroma
plaque formation. The interaction of HDLs with membrane cholesterol transporters is
especially relevant in reducing the intracellular cholesterol content of macrophages
that interact with the atheroma plaque, thus HDL mimetics have focused attention as
a potential therapeutic tool and as an inspirational source for biomedical engineering.
The goal of the present work was to deliver microRNA to foam cells to stimulate ABCA1
expression in order to improve the previously shown effects of 1,2-dipalmitoyl-sn-glycerol-3-phosphocholine
(DPPC) rHDL on promoting cholesterol efflux.
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P147 / #675 E-Posters Topic: 1. PATHOGENESIS OF ATHEROSCLEROSIS / 1.08 Atherosclerosis regression
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© 2021 Published by Elsevier Inc.
