Abstract| Volume 331, e104, August 2021

Delivery of micrornas by reconstituted HDL enhances cholesterol efflux from foam cells in a triple-cell two-dimensional atheroma plaque model

      Background and Aims: Cardiovascular disease (CVD), the leading cause of mortality in industrially developed countries, is primarily caused by atherosclerosis, characterized by an abnormal lipid and inflammatory cell accumulation in the intima, which is associated with atheroma plaque formation. The interaction of HDLs with membrane cholesterol transporters is especially relevant in reducing the intracellular cholesterol content of macrophages that interact with the atheroma plaque, thus HDL mimetics have focused attention as a potential therapeutic tool and as an inspirational source for biomedical engineering. The goal of the present work was to deliver microRNA to foam cells to stimulate ABCA1 expression in order to improve the previously shown effects of 1,2-dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC) rHDL on promoting cholesterol efflux.
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