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Atherosclerosis regression is associated with both infiltration of new leukocytes into the plaque and a shift in macrophage polarization towards a more migratory phenotype

  • Menno Hoekstra
    Correspondence
    Corresponding author.Einsteinweg 55, 2333CC, Leiden, the Netherlands.
    Affiliations
    Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands
    Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands
    Pharmacy Leiden, Leiden, the Netherlands
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  • Ezra J. van der Wel
    Affiliations
    Division of BioTherapeutics, the Netherlands
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  • Miranda Van Eck
    Affiliations
    Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands
    Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands
    Pharmacy Leiden, Leiden, the Netherlands
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Published:June 18, 2022DOI:https://doi.org/10.1016/j.atherosclerosis.2022.06.1013
Atherosclerosis regression is associated with both infiltration of new leukocytes into the plaque and a shift in macrophage polarization towards a more migratory phenotype
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      In light of our mission to find novel therapeutic targets to stimulate atherosclerotic lesion regression, we have reviewed with great interest the data presented by Zhang et al. in Atherosclerosis which suggest that global inhibition of PLTP activity facilitates the disappearance of macrophages from regressing atherosclerotic lesions [
      • Zhang K.
      • Zheng J.
      • Chen Y.
      • Dong J.
      • Li Z.
      • Chiang Y.P.
      • He M.
      • Huang Q.
      • Tang H.
      • Jiang X.C.
      Inducible phospholipid transfer protein deficiency ameliorates atherosclerosis.
      Atherosclerosis. 2021; 324: 9-17
      ].

      Keywords

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      References

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        • He M.
        • Huang Q.
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        • Jiang X.C.
        Inducible phospholipid transfer protein deficiency ameliorates atherosclerosis.
        Atherosclerosis. 2021; 324: 9-17
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      Article Info

      Publication History

      Published online: June 18, 2022
      Accepted: June 10, 2022
      Received: May 23, 2022

      Publication stage

      In Press Journal Pre-Proof

      Identification

      DOI: https://doi.org/10.1016/j.atherosclerosis.2022.06.1013

      Copyright

      © 2022 Elsevier B.V. All rights reserved.

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