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Atherosclerosis regression is associated with both infiltration of new leukocytes into the plaque and a shift in macrophage polarization towards a more migratory phenotype

  • Menno Hoekstra
    Correspondence
    Corresponding author.Einsteinweg 55, 2333CC, Leiden, the Netherlands.
    Affiliations
    Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands
    Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands
    Pharmacy Leiden, Leiden, the Netherlands
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  • Ezra J. van der Wel
    Affiliations
    Division of BioTherapeutics, the Netherlands
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  • Miranda Van Eck
    Affiliations
    Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands
    Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands
    Pharmacy Leiden, Leiden, the Netherlands
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      In light of our mission to find novel therapeutic targets to stimulate atherosclerotic lesion regression, we have reviewed with great interest the data presented by Zhang et al. in Atherosclerosis which suggest that global inhibition of PLTP activity facilitates the disappearance of macrophages from regressing atherosclerotic lesions [
      • Zhang K.
      • Zheng J.
      • Chen Y.
      • Dong J.
      • Li Z.
      • Chiang Y.P.
      • He M.
      • Huang Q.
      • Tang H.
      • Jiang X.C.
      Inducible phospholipid transfer protein deficiency ameliorates atherosclerosis.
      ].

      Keywords

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