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The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan, Shandong, 250012, ChinaThe Second Hospital of Shandong University, Jinan, Shandong, 250033, China
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan, Shandong, 250012, China
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan, Shandong, 250012, China
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan, Shandong, 250012, China
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan, Shandong, 250012, China
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan, Shandong, 250012, China
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan, Shandong, 250012, China
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan, Shandong, 250012, China
Texas Heart Institute at St Luke's Episcopal Hospital, Division of Cardiothoracic Surgery, Michael DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan, Shandong, 250012, China
We found two errors in our paper “Gax gene transfer inhibits vascular remodeling induced by adventitial inflammation in rabbits” published in Atherosclerosis, 2010 Oct; 212(2):398–405. First, a wrong immunohistochemical image was used for FAK in the model control group of Figure 4A, which resulted in a partial overlap with the immunohistochemical image of TGF-β1in the same model control group. Second, a wrong Western blot image for Ras was used in Figure 5B, which resulted in an overlap with the Western blot images of FAK in the same panel. Below you can find the corrected Figures. The raw data of Fig. 4A and 5B are provided in supplemental data to this corrigendum. We apologize to our readers for these careless errors.
Fig. 4Immunohistrochemical staining showing the protein expression levels of signaling transducers and inflammatory cytokines in the model control (n = 7) and Ad-Gax-treated groups (n = 9). (A) Signaling transducers in TGF-Smad, MAPK and integrin pathways exhibited higher expression levels in the model control group than in the Ad-Gax-treated group; (B) Quantitative analysis of the immunohistrochemical results in the model control and Ad-Gax-treated groups (ΔP < 0.05, ΔΔP < 0.01).
Fig. 5Western blot analysis demonstrating the protein expression levels of: (A) TGF-β1, Smad, p38 and NF-κB and (B) integrin, FAK, PYK2, Ras, MEK1 and ERK2. *P < 0.05, **P < 0.01, vs. normal control group (n = 7); ΔP < 0.05, ΔΔP < 0.01, vs. model control group (n = 9); #P < 0.05, ##P < 0.01, vs. Ad-GFP-treated group (n = 9).
Adventitial fibroblasts (AFs) and inflammation play an important role in neointimal formation and vascular remodeling. The present study was aimed to investigate the therapeutic effects and underlying mechanisms of transcriptional regulator Gax gene transfection in aortic remodeling induced by adventitial inflammation.
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