Recently, Liu and colleagues reported the mechanism of endothelial mitophagy inhibition by low shear stress [
]. This finding is important for understanding the role of mitophagy in atherogenesis. We would like to supplement this thought with our own results. We shall provide evidence below that naturally occurring multiply modified low-density lipoprotein (mmLDL) isolated from the blood of atherosclerotic patients and native LDL have different effects on mitophagy.
- Liu W.
- Song H.
- Xu J.
- Guo Y.
- Zhang C.
- Yao Y.
- Zhang H.
- Liu Z.
- Li Y.-C.
Low shear stress inhibits endothelial mitophagy via caveolin-1/miR-7-5p/SQSTM1 signaling pathway.
Atherosclerosis. 2022; 356: 9-17https://doi.org/10.1016/j.atherosclerosis.2022.07.014
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- Low shear stress inhibits endothelial mitophagy via caveolin-1/miR-7-5p/SQSTM1 signaling pathway.Atherosclerosis. 2022; 356: 9-17https://doi.org/10.1016/j.atherosclerosis.2022.07.014
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- The role of mitochondrial mutations in chronification of inflammation: hypothesis and overview of own data.Life. 2022; 12: 1153https://doi.org/10.3390/life12081153
Published online: May 15, 2023
Accepted: May 9, 2023
Received: April 28, 2023
Publication stageIn Press Journal Pre-Proof
© 2023 Elsevier B.V. All rights reserved.
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- Low shear stress inhibits endothelial mitophagy via caveolin-1/miR-7-5p/SQSTM1 signaling pathwayAtherosclerosisVol. 356
- PreviewMitophagy plays a crucial role in mitochondrial homeostasis and is closely associated with endothelial function. However, the mechanism underlying low blood flow shear stress (SS), detrimental cellular stress, regulating endothelial mitophagy is unclear. This study aimed to investigate whether low SS inhibits endothelial mitophagy via caveolin-1 (Cav-1)/miR-7-5p/Sequestosome 1 (SQSTM1) signaling pathway.