Recently, Liu and colleagues reported the mechanism of endothelial mitophagy inhibition
by low shear stress [
[1]
]. This finding is important for understanding the role of mitophagy in atherogenesis.
We would like to supplement this thought with our own results. We shall provide evidence
below that naturally occurring multiply modified low-density lipoprotein (mmLDL) isolated
from the blood of atherosclerotic patients and native LDL have different effects on
mitophagy.Keywords
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References
- Low shear stress inhibits endothelial mitophagy via caveolin-1/miR-7-5p/SQSTM1 signaling pathway.Atherosclerosis. 2022; 356: 9-17https://doi.org/10.1016/j.atherosclerosis.2022.07.014
- Intracellular AIBP (Apolipoprotein A-I binding protein) regulates oxidized LDL (Low-Density lipoprotein)-induced mitophagy in macrophages.ATVB. 2021; 41https://doi.org/10.1161/ATVBAHA.120.315485
- mTOR-dependent oxidative stress regulates oxLDL-induced trained innate immunity in human monocytes.Front. Immunol. 2019; 9: 3155https://doi.org/10.3389/fimmu.2018.03155
- MTORC1 regulates both general autophagy and mitophagy induction after oxidative phosphorylation uncoupling.Mol. Cell Biol. 2017; 37e00441https://doi.org/10.1128/MCB.00441-17
- The role of mitochondrial mutations in chronification of inflammation: hypothesis and overview of own data.Life. 2022; 12: 1153https://doi.org/10.3390/life12081153
Article info
Publication history
Published online: May 15, 2023
Accepted:
May 9,
2023
Received:
April 28,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier B.V. All rights reserved.
ScienceDirect
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- Low shear stress inhibits endothelial mitophagy via caveolin-1/miR-7-5p/SQSTM1 signaling pathwayAtherosclerosisVol. 356
- PreviewMitophagy plays a crucial role in mitochondrial homeostasis and is closely associated with endothelial function. However, the mechanism underlying low blood flow shear stress (SS), detrimental cellular stress, regulating endothelial mitophagy is unclear. This study aimed to investigate whether low SS inhibits endothelial mitophagy via caveolin-1 (Cav-1)/miR-7-5p/Sequestosome 1 (SQSTM1) signaling pathway.
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