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Clinical and metabolic effects of pentaerythritol tetranicotinate in combination with cholesolvin or clofibrate

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      Summary

      Combined treatment of hyperlipidaemia with the nicotinic acid derivative pentaerythritol tetranicotinate (Perycit®) and clofibrate or the clofibrate analogue cholesolvin has been used in 26 ambulant patients with different types of hyperlipidaemia (types IIa, IIb and IV).
      The treatment started with Perycit® 1g × 3 daily followed by cholesolvin 1 g × 2 or vice versa. The two drugs were then given together in the same doses as before and finally clofibrate was substituted for cholesolvin.
      The two types of drugs, Perycit® and cholesolvin or clofibrate respectively, were found to have additive synergistic effects on plasma cholesterol as well as on plasma triglyceride concentration. There was no difference between cholesolvin and clofibrate in this respect.
      The usual side effects like flush were seen with Perycit®, but the combined treatment with Perycit® and cholesolvin or clofibrate produced no additional adverse reactions.

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