Identifying arteriosclerosis and aortic atheromatosis by skin biopsy

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      Photonic and ultrastructural examination of skin biopsies accurately reflect the condition of vascular walls. A normal skin type 0 is the equivalent of normal vessels, while skin types II and III correspond to arteriosclerotic aortic and coronary vessels. The test is primarily valuable to establish whether a premature arteriosclerosis exists.
      Estimate of skin lipids — total lipids and total sterols — is a diagnostic test which permits us to establish the degree of atheroma of an individual. Levels of these lipids and the degree of atheroma run parallel.
      By its histological and biological study, skin biopsy can become an accurate test reliably reflecting the condition of the aorta (atherosclerosis and atheromatosis).

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        • Bouissou H.
        • Pieraggi M.Th.
        • Julian M.
        • Rumeau J.L.
        • Huron R.
        La biopsie cutanée permet-elle de connaître l'état vasculaire?.
        Rev. Europ. Clin. Biol. 1970; 15: 444-453
        • Bouissou H.
        • Pieraggi M.Th.
        • Julian M.
        Le fibroblaste cutané au cours du vieillissement et de certains états pathologiques.
        Ann. Anat. Path. 1971; 16: 373-386
        • Bouissou H.
        • Pieraggi M.Th.
        • Julian M.
        • Darnaud J.
        • Denard Y.
        Intérêt de la biopsie de la peau chez le diabétique.
        Association des Diabétologues de Langue Française, Lyon13 novembre, 1971
        • Bouissou H.
        • Pieraggi M.Th.
        • Julian M.
        • Pendaries I.
        • Seguier L.
        • Salvador M.
        • Dardenne P.
        Intérêt de la biopsie cutanée chez l'insuffisant coronarien.
        Arch. Mal. Cœur Vaisseaux. 1973; 66: 655-661
        • Julian M.
        • Fabre M.Th.
        • Mormede S.
        • Bouissou H.
        Le vieillissement cutané chez les vasculaires cardiaques et cérébraux.
        Arch. Mal. Cœur Vaisseaux. 1970; (Rev. Athérosclér. Artériopathies Périphériques): 29-39
        • Bouissou H.
        • Pieraggi M.Th.
        • Julian M.
        • Pendaries I.
        • Sorbara R.
        Intérêt de la biopsie cutanée dans le dépistage de l'artériosclérose précoce.
        Fol. Angiol. Int. (J. Clin. Angiol.). 1972; 20: 271-278
        • Wroman H.E.
        • Nemecek R.A.
        • Hsia S.L.
        Synthesis of lipids from acetate by human preputial and abdominal skin in vitro.
        J. Lipid Res. 1969; 10: 507
        • Wilkinson D.I.
        Incorporation of acetate 1-14C into fatty acid of isolated epidermal cells.
        J. Invest. Derm. 1970; 54: 132
        • Nicolaides N.
        • Rothman S.
        The site of sterol and squalene synthesis in human skin.
        J. Invest. Derm. 1970; 55: 71
        • Rose H.G.
        • Oklander M.J.
        Improved procedure for extraction of lipids from human erythrocytes.
        J. Lipid. Res. 1965; 6: 428
        • Chen P.S.
        • Toribara T.T.
        • Warner H.
        Microdetermination of phosphorus.
        Anal. Chem. 1956; 28: 1756
        • Lieberman C.
        Ueber das Oxychinonterpen.
        Chem. Ber. 1885; 18: 1803-1809
        • Parker F.
        • Short J.M.
        Xanthomatosis associated with hyperlipoproteinemia.
        J. Invest. Derm. 1970; 55: 71
        • Fulton Jr., J.E.
        • Hsia S.L.
        Potential in exploring the biochemistry of human skin.
        Essays in Biochemistry. 1971; 7: 1