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Aortic cholesterol esterase in rabbits

Effect of duration of cholesterol feeding
  • David Kritchevsky
    Affiliations
    Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pa. 19104 (U.S.A.)

    Harrison Department of Surgical Research, University of Pennsylvania, Philadelphia, Pa. 19174 (U.S.A.)
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  • Shirley A. Tepper
    Affiliations
    Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pa. 19104 (U.S.A.)

    Harrison Department of Surgical Research, University of Pennsylvania, Philadelphia, Pa. 19174 (U.S.A.)
    Search for articles by this author
  • Janet C. Genzano
    Affiliations
    Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pa. 19104 (U.S.A.)

    Harrison Department of Surgical Research, University of Pennsylvania, Philadelphia, Pa. 19174 (U.S.A.)
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  • Himanshu V. Kothari
    Affiliations
    Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pa. 19104 (U.S.A.)

    Harrison Department of Surgical Research, University of Pennsylvania, Philadelphia, Pa. 19174 (U.S.A.)
    Search for articles by this author
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      Summary

      The cholesteryl ester synthesizing (S) and hydrolysing (H) activities of rabbit aorta have been assayed in rabbits fed an atherogenic regimen (2% cholesterol in 6% corn oil). Both synthesis and hydrolysis of cholesteryl esters increase over control levels, but the increase in synthetase activity is much greater than that of hydrolase activity. The S/H ratio is sharply increased after 5–7 days on the atherogenic diet, a time when serum and liver cholesterol levels have risen but no atheromata are grossly visible.

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