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Effect of the sodium salt and ethyl ester of α-p-chlorophenoxyisobutyric acid (clofibrate) on a fat-mobilizing factor in serum

  • Author Footnotes
    * Present address: Department of Biophysics and Biochemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS (Great Britain)
    P.B. Curtis-Prior
    Footnotes
    * Present address: Department of Biophysics and Biochemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS (Great Britain)
    Affiliations
    Department of Medicine, Guy's Hospital Medical School, London SE1 9RT (Great Britain)
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  • Author Footnotes
    * Present address: Department of Biophysics and Biochemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS (Great Britain)
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      Summary

      The sodium salt and ethyl ester of clofibrate (α-p-chlorophenoxyisobutyric acid, CPIB) in concentrations exceeding 10−3M, were found to antagonize the activity of a serum fat mobilizing factor which modulates adipose tissue lipolysis through the mediation of cyclic AMP. It is suggested that CPIB manifests its effects on serum lipolytic activity by action at the cell membrane with subsequent reduction in intracellular cyclic AMP. It is further suggested that this modulation of serum lipolytic activity by CPIB, results in its hypolipidaemic effect.

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