Advertisement

The fatty acid composition of cholesteryl esters, phospholipids and triglycerides of the baboon, Papio ursinus

  • Author Footnotes
    * Present address: National Food Research Institute, C.S.I.R., P.O. Box 395, Pretoria.
    J.P. Kotzé
    Footnotes
    * Present address: National Food Research Institute, C.S.I.R., P.O. Box 395, Pretoria.
    Affiliations
    Division of Physiological Chemistry, National Research Institute for Nutritional Diseases, South African Medical Research Council, Private Bag X380, Prestoria (South Africa)
    Search for articles by this author
  • J.S. Neuhoff
    Affiliations
    Division of Physiological Chemistry, National Research Institute for Nutritional Diseases, South African Medical Research Council, Private Bag X380, Prestoria (South Africa)
    Search for articles by this author
  • G.P. Engelbrecht
    Affiliations
    Division of Physiological Chemistry, National Research Institute for Nutritional Diseases, South African Medical Research Council, Private Bag X380, Prestoria (South Africa)
    Search for articles by this author
  • G.J. Van Der Merwe
    Affiliations
    Division of Physiological Chemistry, National Research Institute for Nutritional Diseases, South African Medical Research Council, Private Bag X380, Prestoria (South Africa)
    Search for articles by this author
  • J.P. Du Plessis
    Affiliations
    Division of Physiological Chemistry, National Research Institute for Nutritional Diseases, South African Medical Research Council, Private Bag X380, Prestoria (South Africa)
    Search for articles by this author
  • L.P. Horn
    Affiliations
    Division of Physiological Chemistry, National Research Institute for Nutritional Diseases, South African Medical Research Council, Private Bag X380, Prestoria (South Africa)
    Search for articles by this author
  • Author Footnotes
    * Present address: National Food Research Institute, C.S.I.R., P.O. Box 395, Pretoria.
      This paper is only available as a PDF. To read, Please Download here.
      Summary
        o.
      • (1)
        Analysis of the sera of more than 100 wild baboons, Papio ursinus, revealed that the cholesteryl esters had the following fatty acid composition: 22.7 palmitic, 5.8 palmitoleic, 10.4 stearic, 24.8 oleic, 31.7 linoleic, 1.0 linolenic, and 5.0% arachidonic acids. The total unsaturated cholesteryl fatty acids comprised 68.4% of the total cholesteryl esters.
      • (2)
        The average fatty acid composition of the phospholipids was as follows: 29.1 palmitic, 3.1 palmitoleic, 21.5 stearic, 16.9 oleic, 20.0 linoleic, 1.1 linolenic and 7.2 arachidonic acids. The total phospholipid contained 48.3% unsaturated acids.
      • (3)
        The fatty acid composition of the triglycerides was the following, i.e. 34.7 palmitic, 7.5 palmitoleic, 11.2 stearic, 32.0 oleic, 14.3 linoleic, 1.3 linolenic and 2.5% arachidonic acids.
      • (4)
        Very low density lipoproteins of baboon sera contained a higher proportion of the saturated fatty acids in cholesteryl esters, phospholipids and triglycerides than the high density lipoproteins.
      • (5)
        In baboon sera the high density lipoprotein fractions contained about 55%, 59% and 80% of the total cholesterol, fatty acids, and phospholipids, respectively. Of the total triglyceride content of baboon sera, about 64% was found in the very low density fraction.

      Key words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Kotzé J.P.
        • Kempff P.G.
        Nutritional regimens and their effects on the lipid metabolism of the baboon Papio ursinus.
        S. Afr. J. Sci. 1974; (In press)
        • Kritchevsky D.
        Experimental atherosclerosis.
        in: Paoletti R. Kritchevsky D. Lipid Pharmacology. Academic Press, New York, N.Y.1964: 63
        • Van der Watt J.J.
        • Kotzé J.P.
        • Kempff P.G.
        • Du Plessis J.P.
        • Laubscher N.F.
        Aortic intimal lesions and serum lipids in wild baboons.
        J. Med. Primatol. 1972; 36: 1
        • Hatch F.T.
        • Lees R.S.
        Practical methods for plasma lipoprotein analysis.
        Advan. Lipid Res. 1968; 6: 1
        • Zlatkis A.
        • Zak B.
        • Boyle A.J.
        A new method for the direct determination of serum cholesterol.
        J. Lab. Clin. Med. 1953; 41: 486
        • Carlson L.A.
        • Wadström L.B.
        Determination of glycerides in blood serum.
        Clin. Chim. Acta. 1959; 4: 197
        • Bartlett G.R.
        Phosphorus assay in column chromatography.
        J. Biol. Chem. 1959; 234: 466
        • Folch J.
        • Lees A.M.
        • Sloane-Stanley G.H.
        A simple method for the isolation and purification of total lipids from animal tissue.
        J. Biol. Chem. 1957; 226: 497
        • Hirsch J.
        • Ahrens Jr., E.H.
        The separation of complex lipid mixtures by the use of silicic acid chromatography.
        J. Biol. Chem. 1958; 233: 311
        • Morrison W.R.
        • Smith L.M.
        Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol.
        J. Lipid Res. 1964; 5: 600
        • Karlson P.
        Kurzes Lehrbuch der Biochemie für Mediziner und Naturwissenscchaftler. Thieme, Stuttgart1962: 194
        • Chapman D.
        Introduction to Lipids. McGraw-Hill, London1969: 72
        • Lindgren F.T.
        • Nichols A.V.
        • Wills R.D.
        Fatty acid distributions in serum lipids and serum lipoproteins.
        J. Biol. Chem. 1971; 246: 5067
        • Goodman De W.S.
        • Shiratori T.
        Fatty acid composition of human plasma lipoprotein fractions.
        J. Lipid Res. 1964; 5: 307
        • O'Brien J.S.
        Cell membranes—composition: structure: function.
        J. Theor. Biol. 1967; 15: 307
        • Eggen D.A.
        • Strong J.P.
        Diet and cholesterol metabolism in young and old baboons.
        Atherosclerosis. 1970; 12: 359
        • Blaton V.
        • Howard A.N.
        • Gresham G.A.
        • Vandamme D.
        • Peeters H.
        Lipid changes in the plasma lipoproteins of baboons given an atherogenic diet, Part 1 (Changes in the lipids of total plasma and of α- and β-lipoproteins).
        Atherosclerosis. 1970; 11: 497
        • Howard A.N.
        • Blaton V.
        • Vandamme D.
        • Van Landschoot N.
        • Peeters H.
        Lipid changes in the plasma lipoproteins of baboons given an atherogenic diet, Part 3 (A comparison between lipid changes in the plasma of the baboon and chimpanzee given atherogenic diets and those in human plasma lipoproteins of Type II hyperlipoproteinemia).
        Atherosclerosis. 1972; 16: 257
        • Hallgren B.
        • Stenhagen S.
        • Svanborg A.
        • Svennerholm L.
        Gas chromatographic analysis of the fatty acid composition of the plasma lipids in normal and diabetic subjects.
        J. Clin. Invest. 1960; 39: 1424
        • Margolis S.
        Structure of very low and low density lipoproteins.
        in: Tria E. Scanu A.M. Structural and Functional Aspects of Lipoproteins in Living Systems. Academic Press, New York, London1969: 391
        • Karmen A.
        • Whyte M.
        • Goodman De W.S.
        Fatty acid esterification and chylomicron formation during fat absorption, Part 1 (Triglycerides and cholesterol esters).
        J. Lipid Res. 1963; 4: 312
        • Spritz N.
        Effects of fatty acid saturation on the distribution of the cholesterol moiety of very low density lipoproteins.
        J. Clin. Invest. 1965; 44: 339
        • Kohout M.
        • Kohoutenova G.K.
        • Heimberg M.
        The regulation of hepatic triglyceride metabolism by free fatty acids.
        J. Biol. Chem. 1971; 246: 5067
      1. (Part 5)
        • Singleton W.S.
        Properties of the liquid state.
        in: Markley K.S. Fatty Acids. Their Chemistry, Properties, Production and Uses. Interscience, New York, London1968: 3419