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Effect of body weight changes on plasma lipids in patients with primary hyperlipoproteinemia

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      Summary

      In 30 untreated patients with type IIb, III, IV, and type V hyperlipoproteinemia plasma lipid concentrations were studied in relation to body weight over a period of up to 5 years. Significant intraindividual correlations were demonstrated between weight index and the logarithms to base 10 of the plasma triglyceride level in 2 of 3 type IIb patients, 2 of 3 type III patients, 8 of 13 type IV patients, and only 1 of 11 type V patients. These correlations were paralleled in about two thirds of the cases by correlations between weight index and the logarithm to base 10 of plasma cholesterol, and in approximately one half of the cases by correlations between weight index and the logarithm to base 10 of plasma phospholipid concentration, both of lower-grade significance. Total starvation led to a pronounced but transient reduction of all plasma lipid fractions, even in those patients without correlations between weight index and plasma lipids.

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