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Serum lipoproteins in pigs on high-cholesterol-high-triglyceride diets

  • Author Footnotes
    * Present address: Department of Clinical Chemistry, The Wolfson Research Laboratories, Queen Elizabeth Medical Centre, Edgbaston, Birmingham B15 2TH (Great Britain).
    G.D. Calvert
    Footnotes
    * Present address: Department of Clinical Chemistry, The Wolfson Research Laboratories, Queen Elizabeth Medical Centre, Edgbaston, Birmingham B15 2TH (Great Britain).
    Affiliations
    Department of Medicine, Auckland University School of Medicine, Auckland (New Zealand)
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  • P.J. Scott
    Correspondence
    Requests for reprints should be addressed to Associate Professor P. J. Scott, Department of Medicine, Auckland Hospital, Auckland (New Zealand).
    Affiliations
    Department of Medicine, Auckland University School of Medicine, Auckland (New Zealand)
    Search for articles by this author
  • Author Footnotes
    * Present address: Department of Clinical Chemistry, The Wolfson Research Laboratories, Queen Elizabeth Medical Centre, Edgbaston, Birmingham B15 2TH (Great Britain).
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      Summary

      A diet including 33% clarified butter and 1% cholesterol induced moderate hypercholesterolaemia in young female pigs. Very low density, low density and high density lipoproteins were isolated quantitatively by preparative ultracentrifugation at solution densities 1.006, 1.063 and 1.21 g/ml respectively. Serum cholesterol and triglyceride, and cholesterol, phospholipid and protein concentrations for each density class, were determined. There was a rise in serum low density lipoproteins, and a minor rise in high density lipoproteins, without any change in lipoprotein density or composition.

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