Arteriosclerosis with metastatic calcification in corriedale sheep in Punjab

      This paper is only available as a PDF. To read, Please Download here.


      An unusual disease has been observed in about 90% of sheep at the breeding farm at Mattewara, Ludhiana, India. Fifty-three out of 57 adult Corriedale sheep examined after death showed plaque formation in the aorta and other arteries. Histopathological examination revealed intense calcification of the medial layer and proliferation of intimal connective tissue. In some cases the lung and kidney also showed calcareous deposits. Analysis of blood plasma revealed a slight rise in the calcium level during the months of June, November and December. Phosphorus values were found to vary up to high normal limits in most of the animals. The disease is suspected to be due to ingestion of some poisonous plant, with effects similar to those of Solanum malacoxylon which is known to cause enteque seco disease in sheep in Argentina.

      Key words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Lignieres J.
        Arteriosclerosis epidemic in sheep.
        Rev. Zootechnica. 1912; 4: 1
        • Marsh H.
        Newsom's Sheep Diseases.
        in: Williams and Wilkins, 1965: 351
        • Camberos H.R.
        • Davis G.K.
        • Djafar M.I.
        • Simpson C.F.
        Soft tissue calcification in guinea pigs fed the poisonous plant Solanum malacoxylon.
        Amer. J. Vet. Res. 1970; 31: 685
        • Trinder P.
        Colorimetric micro-determination of calcium in serum.
        Analyst. 1960; 85: 889
        • Delsal J.L.
        • Manhouri H.
        Comparative study of colorimetric methods for estimation of phosphorus, Part 4 (Estimation of orthophosphate in presence of phosphoric esters).
        Bull. Soc. Chim. Biol. (Paris). 1958; 40: 1623
        • Wooton I.D.P.
        Microanalysis in Medical Biochemistry.
        in: Churchill, Baltimore, Md.1964: 67
        • Spare P.D.
        A study of the titan-yellow dye lake methods for the estimation of serum magnesium.
        Amer. J. Clin. Pathol. 1962; 37: 232
        • Birkeland R.
        Comparative investigations on the concentrations of calcium, magnesium, sodium, potassium in blood plasma and peritoneal fluid of sheep and pig.
        Nord. Vet. Med. 1968; 20: 155
        • Doxey D.L.
        Veterinary Clinical Pathology.
        in: Baillière, Tindall and Cassell, London1971: 218
        • Spector W.S.
        Handbook of Biological Data. Saunders, Philadelphia and London1956: 53
        • Coffin D.L.
        Veterinary Clinical Pathology. Comstock Publishing Company, Ithaca and New York1953
        • Swenson M.J.
        Dukes' Physiology of Domestic Animals. Comstock Publishing Association, Ithaca and London1970: 52
        • Hunt L.M.
        • Gilbert B.N.
        Determining normal levels of calcium and magnesium in sheep and cattle plasma by atomic absorption spectrophotometry.
        Amer. J. Vet. Clin. Pathol. 1968; 2: 231
        • Sharma G.L.
        • Bhalla N.P.
        Occurrence of atherosclerosis in cattle, sheep and goats in India.
        in: International Symposium on Recent Advances in Atherosclerosis, Athens1966
        • Parsad M.C.
        • Rajya B.S.
        • Mohanty G.C.
        Caprine arterial diseases, Part 1 (Spontaneous aortic lesions).
        Exptl. Mol. Pathol. 1972; 17: 14
        • French J.E.
        in: Florey H. General Pathology. Lloyd-Luke (Medical Books), Ltd., London1970: 549
        • Stehbens W.E.
        Intimal proliferation and spontaneous lipid deposition in the cerebral arteries of sheep and steers.
        J. Atheroscler. Res. 1965; 5: 556
        • Moore L.A.
        • Hallman E.T.
        • Sholl L.B.
        Cardiovascular and other lesions in calves fed diets low in magnesium.
        Arch. Pathol. 1938; 26: 820
        • Unglaub I.
        • Syllm-Repoport I.
        • Strassburger I.
        Pathologisch-anatomische Befunde bei experimentellem Magnesium-Mangel des Hundes.
        Virchow's Arch. 1959; 32: 122
        • Smith N.A.
        • Jones T.C.
        Veterinary Pathology. Lea and Febiger, Philadelphia, Pa.1966: 60
        • Blood D.C.
        • Henderson J.A.
        Veterinary Medicine. Baillière, Tindall and Cassell, London1968: 870
        • Carrillo B.J.
        • Worker N.A.
        Enteque seco, arteriosclerosis y calcification metastatica de origen toxico en animales a pastoreo.
        Rev. Inv. Agr. INTA, Argentina, Series. 1967; 4: 9
        • Camberos H.R.
        • Davis G.K.
        • Djafar M.I.
        • Simpson C.F.
        Soft tissue calcification in guinea pigs fed the poisonous plant Solanum malacoxylon.
        Amer. J. Vet. Res. 1970; 31: 685