Abstract
Previous studies have shown that oral administration of 300 mg α-tocopherol/day to
healthy volunteers decreases platelet function and enhances their sensitivity to the
platelet inhibitor, prostaglandin E1, when full dose-response curves to a range of agonist concentrations are made. In
this study, the effects of oral doses of natural α-tocopherol (75, 200 and 400 IU/day)
were studied in order to determine whether the same effects might be achieved with
lower intakes of vitamin E and whether inhibition is related to the platelet levels
of the antioxidant in platelet membranes. Twenty two subjects undertook the supplementation
regime, divided into three units of 2 weeks, each cycling through each of the dosages.
The results show that uptake of vitamin E by the platelets was optimal at 75 IU/day,
correlating with the maximal influence on platelet aggregation and platelet responsiveness
to inhibition by PGE1, increased supplemental levels exerting no greater effects.
Keywords
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Article info
Publication history
Published online: August 16, 2004
Accepted:
April 14,
1999
Received in revised form:
February 23,
1999
Received:
July 27,
1998
Identification
Copyright
© 1999 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
