Abstract
A total of ten healthy elderly subjects ingested one capsule of 600 mg (corresponding
to 150 mg docosahexaenoic acid and 30 mg eicosapentaenoic acid) RO-PUFA triglycerides
per day and ten others ingested one capsule of 600 mg sunflower oil as a placebo for
42 days. In the n-3 polyunsaturated fatty acids (PUFA) group, a significant decrease of systolic blood
pressure was observed, as well as a trend towards a decrease in both platelet activation
and basal formation of thromboxane B2. Also, a slight but significant increase of docosahexaenoic acid was observed in
the phosphatidylethanolamine fraction as well as a significant increase of vitamin
E level after the n-3 PUFA intake. Moreover, the basal production of malondialdehyde significantly decreased.
No modification was observed for all these parameters in the placebo group. We conclude
that a small intake of n-3 PUFA decreased the oxidative stress in platelets of elderly people and could be
beneficial in subjects with atherothrombotic tendencies by lowering the cell peroxide
tone.
Keywords
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Article info
Publication history
Published online: August 16, 2004
Accepted:
April 21,
1999
Received in revised form:
March 4,
1999
Received:
October 8,
1998
Identification
Copyright
© 1999 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
