Abstract
Oxidized low density lipoprotein (oxLDL) has been implicated in the pathogenesis of
atherosclerosis. Recent studies have shown that immunization of animals with oxLDL
results in suppression of atherogenesis. Antibody against oxLDL (oxLDL Ab) is detectable
in human sera, although its biological significance is not well established. We examined
the relationship between oxLDL Ab titer and circulating oxLDL level in 130 healthy
Japanese subjects. OxLDL was measured as apolipoprotein (apo) B-containing lipoproteins
carrying oxidized phosphatidylcholines by a sensitive ELISA. IgG class oxLDL Ab titer
was measured by ELISA. Plasma oxLDL concentration was very low and it corresponded
on average to one to two out of 1000 apoB-containing lipoproteins in plasma. Plasma
oxLDL correlated positively with LDL cholesterol and inversely with oxLDL Ab titer.
These associations remained significant and independent in multiple regression analysis
including age, gender, smoking, and high-density lipoprotein cholesterol. These data
indicate that healthy subjects have a very low concentration of oxLDL in the circulation,
and that oxLDL Ab titer is in an inverse relationship with plasma oxLDL concentration
in this population. Although these results suggest that oxLDL Ab may play a role in
maintaining the low level of plasma oxLDL, its role in atherogenesis awaits further
studies.
Keywords
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Article info
Publication history
Published online: August 16, 2004
Accepted:
June 2,
1999
Received in revised form:
March 3,
1999
Received:
December 18,
1998
Identification
Copyright
© 2000 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
