Effects of age, gender, and lifestyle factors on plasma apolipoprotein A-IV concentrations


      Apolipoprotein (apo) A-IV is a protein component of triglyceride (TG)-rich lipoproteins and high density lipoproteins (HDL). Plasma apo A-IV levels were measured by immunoelectrophoresis and these values were related to other biological variables in 723 middle aged and elderly men and women (more than 90% of them were Caucasian) prior to participation in a lifestyle modification program. Apo A-IV may play an important function in regulating lipid absorption, reverse cholesterol transport, and food intake. The data are consistent with the following concepts: (1) apo A-IV levels are significantly and positively correlated with age (r=0.159, P<0.05) in all subjects, with plasma apo A-I levels in both men (r=0.194, P<0.001) and women (r=0.213, P<0.001), and with apo E (r=0.111, P<0.05) and TG levels (r=0.120, P<0.05) in men; (2) apo A-IV levels are inversely correlated with body mass index (r=0.170, P<0.05) in women; (3) female subjects on hormone replacement therapy have significantly lower plasma apo A-IV levels (by 4.1%, P<0.05) than normal controls; (4) diabetic subjects have significantly higher apo A-IV levels (by 21%, P<0.01) than normal subjects; (5) there is no significant effect of smoking, alcohol intake, and apo A-IV-1/2 genotype on apo A-IV levels. The data indicate that plasma apo A-IV levels are significantly affected by age, diabetes, and hormone replacement therapy.


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