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Direct determination of plasma triglyceride in decompensated diabetes in dogs

  • Author Footnotes
    * Present address: St. Hans Hospital, Dept. E, Roskilde (Denmark).
    A. Randrup
    Footnotes
    * Present address: St. Hans Hospital, Dept. E, Roskilde (Denmark).
    Affiliations
    NOVO Therapeutic Laboratory, Copenhagen N. (Denmark)
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  • Author Footnotes
    * Present address: St. Hans Hospital, Dept. E, Roskilde (Denmark).
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      Summary

      Moderate insulin deficiency caused in diabetic dogs a highly significant increase (P≪0.001) in the plasma triglyceride (determined by a direct method), whereas the slight increase found in the plasma cholesterol was not significant (P>0.05). On the basis of this result and findings reported in the literature, it is suggested that application of plasma triglyceride analysis may be valuable in some studies of lipid metabolism and its relation to atherosclerosis.

      Résumé

      Une déficiency modérée en insuline provoque chez le chien diabétique une augmentation des triglycérides plasmatiques (déterminée par une méthode directe) hautement significative (P ≪ 0.001). En contraste, l'augmentation modérée du cholestérol plasmatique nest pas significative (P > 0.05). D'après ce résultat joint aux faits rapportés dans la littérature, il est suggéré que l'analyse des triglycérides plasmatiques pourrait être utile dans les études du métabolisme des lipides et ses rapports avec l'athérosclérose.

      Zusammenfassung

      Bei diabetischen Hunden verursachte ein mässiges Insulindefizit einen hoch signifikanten (P≪0.001) Anstieg im Triglyceridgehalt des Plasmas (mit einer direkten Methode bestimmt), während der geringe Anstieg des Plasmacholesterins nicht signifikant war (P>0.05). Aufgrund dieses Ergebnisses and der in der Literatur mitgeteilten Befunde wird angenommen, dass die Plasmatriglyceridbestimmung in gewissen Untersuchungen des Lipidstoffwechsels und seiner Beziehung zur Atherosklerose wertvoll sein kann.
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