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Effects of adrenalin chloride on plasma cholesterol and lipoproteins of cholesterol-fed cockerels

  • H.Y.C. Wong
    Affiliations
    Departments of Physiology and Pathology, College of Medicine, Howard University; Armed Forces Institute of Pathology, V. A. Central Laboratory for Anatomic Pathology and Research, Washington, D. C. (U.S.A.)
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  • T.F. Johnson
    Affiliations
    Departments of Physiology and Pathology, College of Medicine, Howard University; Armed Forces Institute of Pathology, V. A. Central Laboratory for Anatomic Pathology and Research, Washington, D. C. (U.S.A.)
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  • C. Sampson
    Affiliations
    Departments of Physiology and Pathology, College of Medicine, Howard University; Armed Forces Institute of Pathology, V. A. Central Laboratory for Anatomic Pathology and Research, Washington, D. C. (U.S.A.)
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  • F.B. Johnson
    Affiliations
    Departments of Physiology and Pathology, College of Medicine, Howard University; Armed Forces Institute of Pathology, V. A. Central Laboratory for Anatomic Pathology and Research, Washington, D. C. (U.S.A.)
    Search for articles by this author
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      Summary

      The effects of injected adrenalin chloride on the plasma cholesterol and α/β-lipoprotein ratio and on aortic and coronary atherosclerosis in cockerels fed plain mash or an atherogenic diet were examined and found to be negligible. Histological examination of the aorta and coronary vessels showed no vascular damage induced or enhanced by the dose of adrenalin chloride in cockerels on plain mash or on the atherogenic regimen.

      Résumé

      Les effets d'injections de chlorhydrate d'adrénaline sur le cholestérol plasmatique, le rapport α/β-lipoproteines et l'athérosclérose aortique et coronarienne des poulets nourris avec un régime athérogène ont été étudiés et trouvés négligeables. L'examen histologique de faorte et des vaisseaux coronaires ne montre pas chez ces animaux de lésions vasculaires imputables ou aggravées par le chlorhydrate d'adrénaline.

      Zusammenfassung

      Es wurden die Wirkungen von injiziertem Adrenalin-Chlorid auf das Cholesterin und den α/β-Lipoprotein-Quotienten and auf die Aorten- and Coronar-Atherosklerose bei Hähnchen untersucht, die mit einem einfachen Mischfutter oder mit einer atherogenen Diät gefüttert waren.
      Diese Wirkungen waren unbedeutend. Die histologische Untersuchung der Aortenund Coronargefässe ergab keine vasculäre Schädigung, die durch das AdrenalinChlorid hervorgerufen oder verstärkt wurde, weder unter Mischfutter noch unter atherogener Diät.
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